1: O2, salcomine / dimethylformamide / 2 h / Ambient temperature 2: methanol / 23 h / Ambient temperature View Scheme

1: O2, salcomine / dimethylformamide / 2 h / Ambient temperature 2: NH4Cl / methanol / 13 h / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4157402', constants.ctx, '0')">cyclohexyl(iPr)NLi</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=0&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: sodium iodide / acetone / 5 h / |Inert atmosphere; |Reflux<br />2: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 0.5 h / -78 - 0 &deg;C / |Inert atmosphere; |Schlenk technique<br />3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 0.33 h / 0 &deg;C / |Inert atmosphere<br />4: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 &deg;C / |Inert atmosphere<br />5: water; sodium hydroxide / methanol / 0.5 h / |Reflux; |Inert atmosphere<br />6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 &deg;C / |Inert atmosphere<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 0.5 h / -78 - 0 &deg;C / |Inert atmosphere; |Schlenk technique<br />2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 0.33 h / 0 &deg;C / |Inert atmosphere<br />3: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 &deg;C / |Inert atmosphere<br />4: water; sodium hydroxide / methanol / 0.5 h / |Reflux; |Inert atmosphere<br />5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 &deg;C / |Inert atmosphere<br /> <br /> &nbsp;