苄氧羰基-脯氨酰-缬氨酸合成路线 （共 11 条）
反应条件
triethylamine in water; acetonitrile T=20°C; 1 h;
参考文献
Katritzky, Alan R.; Todadze, Ekaterina; Angrish, Parul; Draghici, Bogdan
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5794 - 5801
反应条件
1: Z-Pro-OBt With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=0°C; Substitution; 0.5 h; 2: 2-aminoisovaleric acid With sodium perchlorate; triethylamine in N,N-dimethyl-formamide T=20°C; Condensation; 1 h;
参考文献
Raydnov, M. G.; Klimenko, L. V.; Mitin, Yu. V.
Russian Journal of Bioorganic Chemistry, 1999 , vol. 25, # 5 p. 283 - 287
Bioorganicheskaya Khimiya, 1999 , vol. 25, # 5 p. 323 - 328
反应条件
sodium hydroxide in methanol 1 h; Ambient temperature;
参考文献
Shinoda, Ichizo; Fushimi, Akira; Kato, Hironobu; Okai, Hideo; Fukui, Sazuko
Agricultural and Biological Chemistry, 1985 , vol. 49, # 9 p. 2587 - 2596
反应条件
1: 80 percent / NMM, ECF / tetrahydrofuran; dimethylformamide / 1 h on ice bath, then room temperature 2: 78 percent / 2 N sodium hydroxide / methanol / 1 h / Ambient temperature View Scheme
参考文献
Panneman et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 487,499
反应条件
in tetrahydrofuran T=20°C; Basic conditions;
参考文献
Nowshuddin, Shaik; Ram Reddy
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 22 - 25
反应条件
sodium hydroxide; ethanol
参考文献
Panneman et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 487,499
反应条件
hydrogenchloride in ethyl acetate 1.5 h; Ambient temperature;
参考文献
Miyazawa, Toshifumi; Hiramatsu, Shin'ichi; Tsuboi, Yasuhiro; Yamada, Takashi; Kuwata, Shigeru
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 7 p. 1976 - 1982
反应条件
1: 79 percent / isobutoxycarbonyl chloride / tetrahydrofuran 2: 4M-HCl / ethyl acetate / 1.5 h / Ambient temperature View Scheme
参考文献
Miyazawa, Toshifumi; Hiramatsu, Shin'ichi; Tsuboi, Yasuhiro; Yamada, Takashi; Kuwata, Shigeru
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 7 p. 1976 - 1982
反应条件
1: ethyl acetate; diethyl ether; aqueous KHCO3 2: aqueous NaOH; dioxane View Scheme
参考文献
Synge
Biochemical Journal, 1948 , vol. 42, p. 99,101
反应条件
1: ethyl acetate; diethyl ether; aqueous KHCO3 2: aqueous NaOH; dioxane View Scheme
参考文献
Synge
Biochemical Journal, 1948 , vol. 42, p. 99,101
