1: aq. NaOH / methanol / 30 h / Heating 2: 88 percent / 4 h / 160 °C 3: 92 percent / H2 / 10percent Pd/C / methanol / 3 h / 45 °C / 760 Torr 4: 93 percent / HCl / 20 h / Heating View Scheme

1: aq. NaOH / methanol / 30 h / Heating 2: 88 percent / 4 h / 160 °C 3: 92 percent / H2 / 10percent Pd/C / methanol / 3 h / 45 °C / 760 Torr 4: 93 percent / HCl / 20 h / Heating 5: 87 percent / 4-chloropyridine hydrochloride / dioxane / 2.5 h / Heating View Scheme