1: (COCl)2 / CDCl3 / 3 h / Heating 2: 51 percent / CH2Cl2 / 0.5 h / Ambient temperature 3: liquid NH3, Na / tetrahydrofuran / 0.5 h / -78 °C View Scheme

Oxonereg; in 1,4-dioxane; water 15 h; Heating;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11327464', constants.ctx, '0')">Oxonereg;</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102551', constants.ctx, '0')">1,4-dioxane</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />2&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587191', constants.ctx, '0')">dihydrogen peroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a> <br />Oxidation;&nbsp;2&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 2.) KOH / 1.) room temperature, 1 h, 2.) EtOH, 50 deg C, 1 h<br />2: 86 percent / Na₂WO₄-2H₂O, aq. H₂O₂ / 15 h / Ambient temperature; phosphate buffer, pH 5.6<br />3: 94 percent / Oxone / dioxane; H₂O / 2 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 2.) KOH / 1.) room temperature, 1 h, 2.) EtOH, 50 deg C, 1 h<br />2: 86 percent / Na₂WO₄-2H₂O, aq. H₂O₂ / 15 h / Ambient temperature; phosphate buffer, pH 5.6<br />3: 94 percent / Oxone / dioxane; H₂O / 2 h / Heating<br /> <br /> &nbsp;