林可霉素 2,7-二乙酸酯合成路线 （共 119 条）
反应条件
C25H26MoNO3(1+)*I(1-) in tetrachloromethane T=40°C; Inert atmosphere;
参考文献
The Regents of the University of Colorado, a body corporate; Zhang, Wei; Kuthanapillil, Jyothish; Wang, Qi
Patent: US2013/261295 A1, 2013 ;
Location in patent: Paragraph 0138; 0194; 0196 ;
反应条件
pyrrolidine; tetrabutylammomium bromide; [1-cyclohexyl-3-(di-pyridin-2-yl-methyl)-urea][PdCl2] in water T=100°C; 5 h;
参考文献
Gil-Molto, Juan; Najera, Carmen
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 14 p. 1874 - 1882
反应条件
copper(l) iodide; (+/-)-2,2'-diamino-6,6'-dimethylbiphenyl; sodium hydroxide in dimethyl sulfoxide T=115°C; Sonogashira coupling; 24 h; Inert atmosphere;
参考文献
Wang, Bin-Bin; Ye, Yue-Mei; Chen, Jun-Jun; Zhou, Xia-Xia; Lu, Jian-Mei; Shao, Li-Xiong
Bulletin of the Chemical Society of Japan, 2011 , vol. 84, # 5 p. 526 - 530
反应条件
copper(l) iodide; 8-hydroxy-quinoline; sodium salt of phosphorous acid in ethanol T=80°C; Suzuki coupling; 24 h;
参考文献
Wang, Shihua; Wang, Min; Wang, Lei; Wang, Bo; Li, Pinhua; Yang, Jin
Tetrahedron, 2011 , vol. 67, # 26 p. 4800 - 4806
反应条件
4-nitro-phenol; CH3CH2CMo[N(t-Bu)(3,5-C6H3Me2)]3 in various solvent(s) T=30°C; P=1 Torr; 22 h;
参考文献
Zhang, Wei; Kraft, Stefan; Moore, Jeffrey S.
Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 329 - 335
反应条件
copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine in acetonitrile T=20°C; Sonogashira coupling; Inert atmosphere;
参考文献
Chuentragool, Padon; Vongnam, Kunnigar; Rashatasakhon, Paitoon; Sukwattanasinitt, Mongkol; Wacharasindhu, Sumrit
Tetrahedron, 2011 , vol. 67, # 42 p. 8177 - 8182
反应条件
potassium phosphate; copper(l) iodide; 8-hydroxy-quinoline in ethanol T=100°C; Suzuki Coupling; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Liu, Jidan; Dai, Fenglin; Yang, Zhiyong; Wang, Sizhuo; Xie, Kai; Wang, Anwei; Chen, Xiang; Tan, Ze
Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5678 - 5683
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide T=80°C; sila-Sonogashira-Hagihara cross-coupling; 18 h; Inert atmosphere;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
CuI; (PPh3)2PdCl2 in tetrahydrofuran; water
参考文献
Institute of Medicinal Molecular Design, Inc.
Patent: EP1145718 A1, 2001 ;
反应条件
1: 2-methyl-but-3-yn-2-ol With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in toluene T=80°C; Sonogashira coupling; 1 h; 2: para-iodoanisole With sodium hydride T=110°C; Sonogashira coupling;
参考文献
Novak, Zoltan; Nemes, Peter; Kotschy, Andras
Organic Letters, 2004 , vol. 6, # 26 p. 4917 - 4920
