林可霉素 2,7-二乙酸酯合成路线 （共 119 条）
反应条件
copper(l) iodide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride in benzene T=60°C; Sonogashira reaction; 18 h;
参考文献
Mio, Matthew J; Kopel, Lucas C; Braun, Julia B; Gadzikwa, Tendai L; Hull, Kami L; Brisbois, Ronald G; Markworth, Christopher J; Grieco, Paul A
Organic letters, 2002 , vol. 4, # 19 p. 3199 - 3202
反应条件
NW(OC(CF3)2Me)3(DME) in toluene T=95°C; 10 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 130, # 28 p. 8984 - 8999
反应条件
bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide T=80°C; 3 h;
参考文献
Park, Kyungho; Bae, Goun; Moon, Jeongju; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo
Journal of Organic Chemistry, 2010 , vol. 75, # 18 p. 6244 - 6251
反应条件
potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); N,N,N′,N′-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine in 1,4-dioxane T=105°C; Sonogashira coupling; 20 h; Inert atmosphere;
参考文献
Yi, Tao; Mo, Min; Fu, Hai-Yan; Li, Rui-Xiang; Chen, Hua; Li, Xian-Jun
Catalysis Letters, 2012 , vol. 142, # 5 p. 594 - 600
反应条件
Cu(I) 3-methylsalicylate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran T=50°C; 12 h;
参考文献
Savarin; Srogl; Liebeskind
Organic letters, 2001 , vol. 3, # 1 p. 91 - 93
反应条件
1: methoxybenzene With air; Bi(NO3)3·5H2O; iodine; bismuth(III) chloride in acetonitrile T=20°C; 6 h; 2: 4-ethynyl-1-methoxy-benzene With piperidine; bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=70°C; 3 h;
参考文献
Wan, Shun; Wang, Sunewang R.; Lu, Wenjun
Journal of Organic Chemistry, 2006 , vol. 71, # 11 p. 4349 - 4352
反应条件
oxygen; bis(3-methoxysalicylidene)ethylenediaminatocobalt(II) in methanol; benzene 2 h; Ambient temperature;
参考文献
Inada, Akira; Nakamura, Yushin; Morita, Yutaka
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 1041 - 1042
反应条件
tri-tert-butyl phosphine; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=150°C; Sonogashira coupling; 0.166667 h; microwave irradiation;
参考文献
Huang, He; Liu, Hong; Jiang, Hualiang; Chen, Kaixian
Journal of Organic Chemistry, 2008 , vol. 73, # 15 p. 6037 - 6040
反应条件
potassium acetate; palladium diacetate; silver(l) oxide in dichloromethane T=20°C; 12 h; Molecular sieve;
参考文献
Feng, Chao; Loh, Teck-Peng
Chemical Communications, 2010 , vol. 46, # 26 p. 4779 - 4781
反应条件
potassium phosphate; triphenylphosphine; palladium diacetate in dimethyl sulfoxide T=80°C; 24 h;
参考文献
Shirakawa, Eiji; Kitabata, Takaaki; Otsuka, Hidehito; Tsuchimoto, Teruhisa
Tetrahedron, 2005 , vol. 61, # 41 p. 9878 - 9885
