林可霉素 2,7-二乙酸酯合成路线 （共 119 条）
反应条件
potassium carbonate; 4-(4-methoxyphenyl)anisole; palladium diacetate in tetrahydrofuran 12 h; Heating;
参考文献
Zhang, Weiwei; Wu, Huayue; Liu, Zhiqing; Zhong, Ping; Zhang, Lin; Huang, Xiaobo; Cheng, Jiang
Chemical Communications, 2006 , # 46 p. 4826 - 4828
反应条件
phosphorous acid trimethyl ester T=215°C;
参考文献
Tong, Ling; Ho, Douglas M.; Vogelaar, Nancy J.; Schutt, Clarence E.; Pascal Jr., Robert A.
Journal of the American Chemical Society, 1997 , vol. 119, # 31 p. 7291 - 7302
反应条件
potassium carbonate; i-Pr2NPPh2; palladium diacetate in tetrahydrofuran
参考文献
Zhang, Weiwei; Wu, Huayue; Liu, Zhiqing; Zhong, Ping; Zhang, Lin; Huang, Xiaobo; Cheng, Jiang
Chemical Communications, 2006 , # 46 p. 4826 - 4828
反应条件
1: 100 percent / methanol / Irradiation View Scheme
参考文献
Chemical Communications, , # 4 p. 454 - 456
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=90°C; 2 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Jadhav, Deepak N.; Dasgupta, Priyabrata
Organic Letters, 2010 , vol. 12, # 9 p. 2048 - 2051
反应条件
copper(l) iodide; potassium carbonate; triphenylphosphine in dimethyl sulfoxide T=90°C; 24 h; Inert atmosphere;
参考文献
Qu, Xiaoming; Li, Tingyi; Sun, Peng; Zhu, Yan; Yang, Hailong; Mao, Jincheng
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6938 - 6942
反应条件
n-butyl-magnesium chloride; sodium methylate; sodium; Ca(OH)2 in tetrahydrofuran T=0°C; Sonogashira Cross-Coupling; 0.0916667 h; Inert atmosphereReflux;
参考文献
Jin, Guanyi; Zhang, Xuxue; Cao, Song
Organic Letters, 2013 , vol. 15, # 12 p. 3114 - 3117
反应条件
potassium tert-butylate T=195°C; 2 h;
参考文献
Kaufman, Robert J.; Sidhu, Ravinder S.
Journal of Organic Chemistry, 1982 , vol. 47, # 25 p. 4941 - 4947
反应条件
2,6-di-tert-butyl-4-methyl-phenol; lithium chloride; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane 5 h; Heating;
参考文献
Chabre, Yoann M.; Brisebois, Patrick P.; Abbassi, Leila; Kerr, Sheena C.; Fahy, John V.; Marcotte, Isabelle; Roy, Rene
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 724 - 727
反应条件
n-butyllithium; isopropylamine in tetrahydrofuran; hexane T=15°C; 1.5 h;
参考文献
Silverberg, Lee J.; Wu, Guangzhong; Rheingold, Arnold L.; Heck, Richard F.
Journal of Organometallic Chemistry, 1991 , vol. 409, # 3 p. 411 - 420
