林可霉素 2,7-二乙酸酯合成路线 （共 119 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; palladium dichloride; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in dimethyl sulfoxide T=120°C; 24 h; Inert atmosphere;
参考文献
RSC Advances, , vol. 4, # 26 p. 13738 - 13741
反应条件
Raney-Nickel W-2B in benzene Heatingalso from other p-dithioanisic acid alkylesters;
参考文献
Latif, K. A.; Ali, M. Umar
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 5 p. 471 - 473
反应条件
Raney-Nickel W-2B in benzene Heating;
参考文献
Latif, K. A.; Ali, M. Umar
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 5 p. 471 - 473
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in N,N-dimethyl-formamide T=20°C; Sonogashira coupling; 6 h; Inert atmosphereSealed tube; 2: With silver carbonate in N,N-dimethyl-formamide T=130°C; 20 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 76, # 7 p. 2214 - 2219
反应条件
1: copper(l) iodide; palladium diacetate; caesium carbonate; silver carbonate / DCE / 24 h / 80 °C 2: sodium hydroxide / ethanol; water / 0.5 h / 20 °C 3: copper(l) iodide; potassium carbonate; triphenylphosphine / dimethyl sulfoxide / 24 h / 90 °C / Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 20 p. 6938 - 6942
反应条件
palladium diacetate; potassium carbonate; 1-n-butyl-3-methylimidazolium tetrafluoroborate in ethanol T=70°C; Sonogashira coupling; 72 h; Inert atmosphereSealed vessel;
参考文献
Catalysis Letters, , vol. 141, # 4 p. 549 - 553
反应条件
potassium tert-butylate in diethylene glycol dimethyl ether T=0°C; Rate constant;
参考文献
Journal of Organic Chemistry, , vol. 35, # 4 p. 939 - 943
反应条件
ammonia; sodium in diethyl ether
参考文献
Journal of the Chemical Society, , p. 3712 - 3718
反应条件
1: n-BuLi, HMDS / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C to r.t., 30 min 2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -60 - 0 °C View Scheme
参考文献
Synthesis, , # 3 p. 271 - 274
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere 2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 120 h / Inert atmosphere View Scheme
参考文献
Dalton Transactions, , vol. 39, # 40 p. 9493 - 9504
