林可霉素 2,7-二乙酸酯合成路线 （共 119 条）
反应条件
1: potassium carbonate / methanol / 12 h / 20 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0); triethylamine; copper(I) bromide / 4 h / 90 °C / Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 25 p. 7032 - 7040
反应条件
1: potassium hydroxide / ethanol; water / 5 h / 20 °C 2: [bis(acetoxy)iodo]benzene / dichloromethane / 18 h / 20 °C / |Irradiation; |Green chemistry View Scheme
参考文献
RSC Advances, , vol. 3, # 13 p. 4311 - 4320
反应条件
1.1: n-butyllithium / tetrahydrofuran; methanol; hexane / 0.5 h / -74 °C / |Inert atmosphere; |Automated synthesizer 1.2: 1 h / 15 °C / |Automated synthesizer; |Inert atmosphere 2.1: n-butyllithium / methanol; hexane / 0.5 h / -74 - 0 °C / |Automated synthesizer; |Inert atmosphere 2.2: 2 h / 0 °C / |Automated synthesizer; |Inert atmosphere 3.1: lithium diisopropyl amide / methanol / 2 h / -78 °C / |Inert atmosphere; |Automated synthesizer View Scheme
参考文献
Organic Process Research and Development, , vol. 4, # 5 p. 337 - 341
反应条件
dihydrogen peroxide; triethylamine
参考文献
Karmarkar, Pradeep G.; Thakar, Alka A.; Wadia, Murzban S.
Tetrahedron Letters, 1981 , vol. 22, # 24 p. 2301 - 2302
反应条件
1: 84 percent / Br2 / CHCl3; CCl4 / 0 °C / Irradiation 2: 100 percent / NaN3, 1,4-diazabicyclo<2.2.2>octane / acetone / 2.5 h / Heating 3: 115 - 125 °C View Scheme
参考文献
Liebigs Annalen der Chemie, , # 4 p. 367 - 374
反应条件
1: 100 percent / NaN3, 1,4-diazabicyclo<2.2.2>octane / acetone / 2.5 h / Heating 2: 115 - 125 °C View Scheme
参考文献
Liebigs Annalen der Chemie, , # 4 p. 367 - 374
反应条件
1: 0.08 h / Heating 2: 36 percent / Raney-nickel W-2B / benzene / Heating; also from other p-dithioanisic acid alkylesters View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 23, # 5 p. 471 - 473
反应条件
1: NaOEt / benzene 2: Na, liq. NH3 / diethyl ether View Scheme
参考文献
Journal of the Chemical Society, , p. 3712 - 3718
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene in water; benzene 18 h; Inert atmosphereSchlenk technique;
参考文献
Journal of the American Chemical Society, , vol. 135, # 12 p. 4628 - 4631
反应条件
1: sodium hydride; nitrobenzene / mineral oil; tetrahydrofuran / 3 h / 0 °C / |Reflux 2: potassium tert-butylate / tetrahydrofuran / 1 h / |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 9 p. 1740 - 1747
