3-吡啶基(2-噻吩基)甲酮合成路线 （共 4 条）
反应条件
1: With n-butyllithium in diethyl ether; hexane T=-78 - 0°C; 0.5 h; 2: With hydrogenchloride in diethyl ether; hexane pH=1; 0.5 h;
参考文献
Jakobsen, Palle; Madsen, Peter; Andersen, HenrikSune
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 357 - 362
反应条件
potassium phosphate; oxygen; copper diacetate; p-toluidine; sodium sulfate in dimethyl sulfoxide T=140°C; 6 h; Sealed tube;
参考文献
Maji, Arun; Rana, Sujoy; Akanksha; Maiti, Debabrata
Angewandte Chemie - International Edition, 2014 , vol. 53, # 9 p. 2428 - 2432
Angew. Chem., 2014 , vol. 126, # 9 p. 2460 - 2464,5
反应条件
n-butyllithium
1) ether, THF, 1 h, -110 deg C, 2) CHCl3, 3 h, -110 deg C; Yield given. Multistep reaction;
参考文献
Sauter, Fritz; Stanetty, Peter; Sittenthaler, Wilhelm; Waditschatka, Rudolf
Monatshefte fuer Chemie, 1988 , vol. 119, p. 1427 - 1438
反应条件
sodium hydride
1.) DMSO, RT, 10 min, 2.) DMSO, RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kato, Kaneyoshi; Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Nishikawa, Kohei
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 287 - 294
