3-氯-4-异丙氧基苯甲酸合成路线 （共 12 条）
反应条件
N-chloro-succinimide in N,N-dimethyl-formamide
参考文献
Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
反应条件
1: With sodium hydroxide; water in methanol T=60°C; 2 h; 2: With hydrogenchloride in water T=20°C;
参考文献
WO2008/128951 A1, ;
Page/Page column 35 ;
WO 2008/128951 A1
反应条件
1: With sodium hydroxide in ethanol T=60°C; 2 h; 2: With acetic acid in water pH=5;
参考文献
WO2011/72488 A1, ;
Page/Page column 16; 29 ;
WO 2011/072488 A1
反应条件
1: With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20°C; 2: With sodium hydroxide; water in methanol; water T=20°C; 3: in water pH=1; Acidic conditions;
参考文献
WO2009/80725 A1, ;
Page/Page column 31-32 ;
WO 2009/080725 A1
反应条件
sodium hydroxide in methanol
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C 2.1: sodium hydroxide / methanol / 20 °C 2.2: pH 1 - 2 / Acidic conditions View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C 2.1: sodium hydroxide / ethanol / 2 h / 60 °C 2.2: pH 5 View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 50 °C 1.2: 50 °C 2.1: water; potassium hydroxide / dimethyl sulfoxide / 80 - 85 °C 2.2: 50 - 60 °C 3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 22 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 5 p. 1254 - 1263
反应条件
1.1: water; potassium hydroxide / dimethyl sulfoxide / 80 - 85 °C 1.2: 50 - 60 °C 2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 22 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 5 p. 1254 - 1263
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 45 °C 2: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C 3: tetrabutylammomium bromide; sodium hydrogencarbonate / acetonitrile / 26 h / Reflux; Large scale reaction View Scheme
参考文献
Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
