3-氰基-4-异丙氧基苯甲酸甲酯合成路线 （共 13 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=50°C; 16 h;
参考文献
CYTOKINETICS, INC.
Patent: WO2007/56056 A2, 2007 ;
Location in patent: Page/Page column 52-53 ;
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=90°C;
参考文献
CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/107762 A2, 2005 ;
Location in patent: Page/Page column 253-254 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=90°C; 14 h;
参考文献
Exelixis, Inc.
Patent: US2010/249071 A1, 2010 ;
Location in patent: Page/Page column 60-61 ;
反应条件
1: With diazomethyl-trimethyl-silane in dichloromethane T=0 - 20°C; 1.8 h; 2: With acetic acid in dichloromethane T=20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DHAR, T.G. Murali; XIAO, Hai-Yun; WATTERSON, Scott Hunter; KO, Soo S.; DYCKMAN, Alaric J.; LANGEVINE, Charles M.; DAS, Jagabandhu; CHERNEY, Robert J.
Patent: WO2011/59784 A1, 2011 ;
Location in patent: Page/Page column 142 ;
WO 2011/059784 A1
反应条件
water; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene in DMF (N,N-dimethyl-formamide) T=120°C; 48 h;
参考文献
WO2005/58848 A1, ;
Page/Page column 46-47 ;
WO 2005/058848 A1
反应条件
1: sodium cyanide; methyl 3-Iodo-4-hydroxybenzoate With copper (I) cyanide in N,N-dimethyl-formamide T=120°C; 24 h; Inert atmosphere; 2: 2-iodo-propane With potassium carbonate in N,N-dimethyl-formamide T=90°C; 12 h; Cooling with ice;
参考文献
US2012/283297 A1, ;
Page/Page column 17 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; Inert atmosphere;
参考文献
WO2011/72488 A1, ;
Page/Page column 16; 25 ;
WO 2011/072488 A1
反应条件
in 1-methyl-pyrrolidin-2-one
反应条件
1: iodine cloride; acetic acid / 20 - 65 °C 2: sodium cyanide / N,N-dimethyl-formamide / 24 h / 120 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1: hydrogenchloride / 20 °C 2: potassium carbonate / acetonitrile / Reflux 3: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 120 °C / Inert atmosphere View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
