2-三苯基膦乙烯基丙酸乙酯合成路线 （共 81 条）
反应条件
diazomethane
1.) CHCl3, reflux, 21 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tsuboi, Sadao; Fukumoto, Hirohumi; Wada, Hiroshi; Takeda, Akira; Fukuyama, Keiichi
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 689 - 696
反应条件
1.) CHCl3, reflux, 21 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tsuboi, Sadao; Fukumoto, Hirohumi; Wada, Hiroshi; Takeda, Akira; Fukuyama, Keiichi
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 689 - 696
反应条件
diisobutylaluminium hydride in tetrahydrofuran; hexane; dichloromethane
参考文献
Abbott Laboratories
Patent: US5214204 A1, 1993 ;
US 5214204 A
反应条件
1: triphenyl(1-[ethoxycarbonyl]ethylidene)phosphorane With N-ethyl-N,N-diisopropylamine in tert-butyl methyl ether
T=7 - 20°C; Wittig Olefination; Large scale;
2: 4-fluorophenylacetic acid chloride in tert-butyl methyl ether; toluene
T=5 - 7°C; Wittig Olefination; 2.8 h; Large scale;
参考文献
Shu, Lianhe; Wang, Ping; Gu, Chen; Liu, Wen; Alabanza, Lady Mae; Zhang, Yingchao
Organic Process Research and Development, 2013 , vol. 17, # 4 p. 651 - 657
反应条件
in dichloromethane
T=50°C; 11 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Volkonskii, A. Yu.; Mysov, E. I.; Rokhlin, E. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 6 p. 1246 - 1257
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 6 p. 1356 - 1367
反应条件
in dichloromethane
T=20°C; 0.25 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Volkonskii, A. Yu.; Mysov, E. I.; Rokhlin, E. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 6 p. 1246 - 1257
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 6 p. 1356 - 1367
反应条件
in benzene
reflux; Title compound not separated from byproducts;
参考文献
Venkataraman, Hemalatha; Cha, Jin K.
Tetrahedron Letters, 1989 , vol. 30, # 27 p. 3509 - 3512
参考文献
Fell, Stephen C. M.; Harbridge, John B.
Tetrahedron Letters, 1990 , vol. 31, # 29 p. 4227 - 4228
反应条件
in dichloromethane
T=50°C; 8 h;
参考文献
Volkonskii, A. Yu.; Mysov, E. I.; Rokhlin, E. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 6 p. 1246 - 1257
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 6 p. 1356 - 1367
反应条件
in dichloromethane 16 h; Ambient temperature;
参考文献
Ksander, Gary M.; Ghai, Raj D.; deJesus, Reynalda; Diefenbacher, Clive G.; Yuan, Andrew; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1689 - 1700
