(2-甲基-1-氮丙啶基)(苯基)甲酮合成路线 （共 28 条）
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: (2-methylaziridin-1-yl)(phenyl)methanone in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
1.2: 72 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 86 percent / Br2; AcOH / 3 h / 80 °C
3.1: 84 percent / dimethylformamide / 14 h / 20 °C
View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene
2 h; Heating;
参考文献
Werry, Juergen; Stamm, Helmut; Lin, Pen-Yuan; Falkenstein, Reinhard; Gries, Stefan; Irngartinger, Hermann
Tetrahedron, 1989 , vol. 45, # 16 p. 5015 - 5028
反应条件
sodium in tetrahydrofuran
168 h; Further byproducts given;
参考文献
Lin, Pen-Yuan; Bellos, Konstantinos; Werry, Juergen; Assithianakis, Petros; Weiss, Rainer; Mall, Thomas; Bentz, Gunther; Stamm, Helmut
Journal fur Praktische Chemie - Chemiker - Zeitung, 1996 , vol. 338, # 3 p. 270 - 278
反应条件
sodium in tetrahydrofuran
168 h; Yield given. Further byproducts given;
参考文献
Lin, Pen-Yuan; Bellos, Konstantinos; Werry, Juergen; Assithianakis, Petros; Weiss, Rainer; Mall, Thomas; Bentz, Gunther; Stamm, Helmut
Journal fur Praktische Chemie - Chemiker - Zeitung, 1996 , vol. 338, # 3 p. 270 - 278
反应条件
sodium in tetrahydrofuran
168 h; Yield given. Further byproducts given;
参考文献
Lin, Pen-Yuan; Bellos, Konstantinos; Werry, Juergen; Assithianakis, Petros; Weiss, Rainer; Mall, Thomas; Bentz, Gunther; Stamm, Helmut
Journal fur Praktische Chemie - Chemiker - Zeitung, 1996 , vol. 338, # 3 p. 270 - 278
反应条件
lithium anthracene hydride in tetrahydrofuran; hexane
Yield givenFurther byproducts given. Yields of byproduct given;
参考文献
Lin; Stamm
Journal of Chemical Research - Part S, 1998 , # 10 p. 646 - 647
反应条件
n-butyllithium
1.) THF, hexane, 2.) THF, hexane; Yield givenMultistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Lin; Stamm
Journal of Chemical Research - Part S, 1998 , # 10 p. 646 - 647
反应条件
>150 deg C; further aziridines; Product distribution;
参考文献
Lygo, Barry
Tetrahedron, 1995 , vol. 51, # 47 p. 12859 - 12868
反应条件
in tetrahydrofuran
T=-20 - 0°C;
参考文献
Wattanasin, S.; Kathawala, F.G.
Tetrahedron Letters, 1984 , vol. 25, # 8 p. 811 - 814
