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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
21384-43-0
合成路线
（共 23 条）
75-55-8
2-甲基氮丙啶
+
1711-06-4
间甲基苯甲酰氯
→
反应条件
21384-43-0
反应条件
sodium hydroxide in diethyl ether T=0°C;
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Naruo, Ken-Ichi; Igaki, Keiko; Watanabe, Yasumasa; Kimura, Hiroyuki; Kawamoto, Tomohiro; Ohkawa, Shigenori
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 4 p. 410 - 418
108-89-4
4-甲基吡啶
+
21384-43-0
→
反应条件
216529-53-2
2-吡啶-4-基-1-间甲苯乙酮
反应条件
1: 4-Methylpyridine With lithium diisopropyl amide in tetrahydrofuran; hexane T=-10°C; 0.333333 h; 2: 1-(3-methylbenzoyl)-2-methylaziridine in tetrahydrofuran; hexane T=-78°C; 1 h;
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
21384-43-0
→
反应条件
303162-85-8
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 62 percent / dimethylformamide / 14 h / 20 °C 4.1: Et3N / tetrahydrofuran / 3 h / 20 °C 5.1: HCl / tetrahydrofuran; H2O / 14 h / 40 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
21384-43-0
→
反应条件
303162-74-5
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 60 percent / dimethylformamide / 14 h / 20 °C 4.1: 88 percent / Et3N / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
21384-43-0
→
反应条件
303162-40-5
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 71 percent / dimethylformamide / 14 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
21384-43-0
→
反应条件
303162-47-2
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 62 percent / dimethylformamide / 14 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
21384-43-0
→
反应条件
303162-80-3
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 60 percent / dimethylformamide / 14 h / 20 °C 4.1: 75 percent / Et3N / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
21384-43-0
→
反应条件
303162-39-2
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 60 percent / dimethylformamide / 14 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 5966 - 5979
21384-43-0
→
反应条件
303163-16-8
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 71 percent / dimethylformamide / 14 h / 20 °C 4.1: 77 percent / Et3N / tetrahydrofuran / 1 h / 20 °C 5.1: 35 percent / LiAlH4; AlCl3 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
21384-43-0
+
90101-20-5
N-(4-甲基-2-吡啶基)-氨基甲酸-1,1-二甲基乙酯
→
反应条件
303162-37-0
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: 1-(3-methylbenzoyl)-2-methylaziridine in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1364949 A1, 2003 ;
Location in patent: Page/Page column 80 ;
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