5-溴-6-[1,3]二氧烷-2-基-苯并[1,3]间二氧杂环戊烯合成路线 （共 11 条）
反应条件
toluene-4-sulfonic acid in toluene Heating;
参考文献
Yoda, Hidemi; Nakahama, Akira; Koketsu, Tomomi; Takabe, Kunihiko
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4667 - 4669
反应条件
4-methylbenzene sulfonic acid monohydrate in ethylene glycol; toluene
参考文献
Bearsden Bio, Inc.
Patent: US6048853 A1, 2000 ;
反应条件
toluene-4-sulfonic acid
参考文献
Kita, Yasuyuki; Arisawa, Mitsuhiro; Gyoten, Michiyo; Nakajima, Makiko; Hamada, Ryuji; Tohma, Hirofumi; Takada, Takeshi
Journal of Organic Chemistry, 1998 , vol. 63, # 19 p. 6625 - 6633
反应条件
in N,N-dimethyl-formamide
参考文献
Le, Thanh Nguyen; Gang, Seong Gyoung; Cho, Won-Jea
Tetrahedron Letters, 2004 , vol. 45, # 13 p. 2763 - 2766
反应条件
in N,N-dimethyl-formamide Rosenmund von Braun reaction; 3 h; Heating;
参考文献
Le, Thanh Nguyen; Cho, Won-Jea
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 4 p. 476 - 480
反应条件
1.1: n-butyllithium / tetrahydrofuran / -78 - -40 °C
1.2: 1 h / -78 °C
2.1: water / acetone / 1 h
3.1: hydrazine / ethanol / 3 h / 0 - 23 °C
View Scheme
参考文献
Bunce, Richard A.; Harrison, Todd; Nammalwar, Baskar
Heterocyclic Communications, 2012 , vol. 18, # 3 p. 123 - 126
反应条件
1: n-BuLi, I2 / hexane; tetrahydrofuran
2: 20percent aq. HCl / methanol; benzene / 16 h
3: 97 percent / NaBH4 / propan-2-ol / 16 h / Heating
4: 87 percent / HCl / acetic acid; CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
反应条件
1: n-BuLi, I2 / hexane; tetrahydrofuran
2: 20percent aq. HCl / methanol; benzene / 16 h
3: 97 percent / NaBH4 / propan-2-ol / 16 h / Heating
View Scheme
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
反应条件
1: 1.) n-BuLi / 1.) -60 deg C, ether
2: KOt-Bu / tetrahydrofuran
3: aq. HCl, CH2Cl2
4: 66 percent / NaOMe, MeOH / tetrahydrofuran / 5 °C
5: 55 percent / xylene / Heating
6: 80 percent / sodium cyanoborohydride / acetic acid
7: 70 percent / DIBAL / toluene / -70 °C
8: 51 percent / Ph2P(CH3)2PPh2 / (Ph3P)Rh(CO)Cl / xylene / Heating
View Scheme
参考文献
Moody, Christopher J.; Warrellow, Graham J.
Tetrahedron Letters, 1987 , vol. 28, # 48 p. 6089 - 6092
反应条件
1.1: n-BuLi
1.2: I2
2.1: H3O(1+)
View Scheme
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
