1.1: (+)-(Ipc)2BH / tetrahydrofuran / 2 h / -35 - 0 °C 1.2: MeCHO / tetrahydrofuran / 0 - 40 °C 1.3: 75 percent / tetrahydrofuran / 1 h / 20 °C 2.1: NiCl2(PPh3)2 / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C 3.1: tetrahydrofuran / 20 °C 4.1: 83 percent / TBAF / tetrahydrofuran / 20 °C View Scheme

<b>Multi-step reaction with 6 steps<br /> </b>1: 99 percent / imidazole / dimethylformamide / 20 &deg;C<br />2: 100 percent / quinoline; H₂ / 5percent Pd/BaSO₄ / methanol / 2 h / 20 &deg;C<br />3: TBAF / tetrahydrofuran / 20 &deg;C<br />4: NaOH / tetrahydrofuran / 3 h / 20 &deg;C<br />5: 62 percent / diethyl ether / 2 h / 0 &deg;C<br />6: 93 percent / imidazole / dimethylformamide / 20 &deg;C<br /> <br /> &nbsp;