3-乙基-四氢吡喃-4-酮合成路线 （共 2 条）
反应条件
1: tetrahydro-pyran-4-one With lithium diisopropyl amide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=-78°C; 0.5 h; Inert atmosphere; 2: ethyl iodide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=-78 - 20°C; 12 h;
参考文献
ABBOTT LABORATORIES; ABOTT LABORATORIES TRADING (SHANGHAI)COMPANY, LTD.; MEYER, Michael D.; WANG, Xueqing; GUO, Tao; WEI, Robert; WANG, Lijuan Jane
Patent: WO2013/149376 A1, 2013 ;
Location in patent: Page/Page column 110 ;
反应条件
1: 4H-pyran-4-one With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.0833333 h; 2: ethyl iodide in tetrahydrofuran T=0°C; 2 h; 3: With ammonium chloride in tetrahydrofuran; water
参考文献
MERCK and CO., INC.; MERCK SHARP and DOHME LIMITED
Patent: WO2003/93231 A2, 2003 ;
Location in patent: Page/Page column 94 ;
WO 03/093231 A2
