2'-O-甲基鸟苷水合物合成路线 （共 21 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 0.25 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 18 p. 2779 - 2788
反应条件
1: triethylamine; 4-dimethylaminopyridine / CH2Cl2 / 8 h / 20 °C 2: 2-tBuN-2-Et2N-1,3-dimethylperhydro-1,3,2-diazaphosphorine / acetonitrile / 1.5 h 3: tetrabutylammonium fluoride / tetrahydrofuran View Scheme
参考文献
Bioorganic & Medicinal Chemistry Letters, , vol. 7, # 4 p. 425 - 428
反应条件
1: 2-tBuN-2-Et2N-1,3-dimethylperhydro-1,3,2-diazaphosphorine / acetonitrile / 1.5 h 2: tetrabutylammonium fluoride / tetrahydrofuran View Scheme
参考文献
Bioorganic & Medicinal Chemistry Letters, , vol. 7, # 4 p. 425 - 428
反应条件
in N,N-dimethyl-formamide T=70°C; 1 h; Further byproducts given;
参考文献
Journal of Organic Chemistry, , vol. 45, # 19 p. 3865 - 3868
反应条件
1: 65 percent / NaH / dimethylformamide; CH2Cl2 / 3 h / -20 °C 2: 65 percent / 1,4-diazabicyclo[2.2.2]octane / H2O / 0.75 h / 90 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 8 p. 1047 - 1056
反应条件
1: 78 percent / DBU / acetonitrile / 9 h / Ambient temperature 2: 60 percent / TsOH / CH2Cl2; methanol / 0.25 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 79, # 8 p. 2114 - 2136
反应条件
1: 83 percent / NaHMDS / dimethylformamide / 5 h / -40 - -27 °C 2: 91 percent / Et3N*3HF / tetrahydrofuran / 14 h / 35 °C View Scheme
参考文献
Nucleosides, nucleotides and nucleic acids, , vol. 22, # 5-8 p. 583 - 587
反应条件
1: 51 percent / SnCl2*2H2O / dimethylformamide; 1,2-dimethoxy-ethane / 50 °C 2: 86 percent / adenosine deaminase / dimethylsulfoxide; H2O / 72 h / Ambient temperature; 0.1M sodium phosphate buffer View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 59, p. 3360 - 3364
反应条件
in methanol; N,N-dimethyl-formamide T=70°C; 1 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2787 - 2792
反应条件
in methanol; N,N-dimethyl-formamide T=70°C; 1 h; Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2787 - 2792
