(1-戊基)三苯基溴化磷合成路线 （共 78 条）
反应条件
1: (i) Na<N(SiMe3)2>, THF, (ii) /BRN= 1746480/ 2: 9-BBN / tetrahydrofuran 3: Py / 3 h / Heating View Scheme
参考文献
Bestmann; Kantardjiew; Roesel; et al.
Chemische Berichte, 1978 , vol. 111, # 1 p. 248 - 253
反应条件
1.1: sodium amide / tetrahydrofuran / 4 h / Heating 1.2: tetrahydrofuran / -78 °C 2.1: mCPBA / diethyl ether / 1 h / 20 °C 2.2: aq. HCl / tetrahydrofuran / 2 h / 20 °C 3.1: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 24 h / 20 °C 4.1: 1.13 g / PhSO2Cl; pyridine 5.1: 99 percent / H2 / Pd/C View Scheme
参考文献
Dirat; Kouklovsky; Langlois, Yves
Organic Letters, 1999 , vol. 1, # 5 p. 753 - 755
反应条件
1: n-pentyltriphenylphosphonium bromide With sodium hydride in tetrahydrofuran; dimethyl sulfoxide T=10 - 25°C; 2: 5-oxopent-1-yl acetate in tetrahydrofuran; dimethyl sulfoxide Wittig reaction; 24 h;
参考文献
Tortajada, Amparo; Mestres, Ramon; Iglesias-Arteaga, Martin A.
Synthetic Communications, 2003 , vol. 33, # 10 p. 1809 - 1814
反应条件
1: 1.) sodiobis(trimethylsilyl)amide / 1.) THF, 50-55 deg C, 60 min, 2.) -78 deg C, 30 min; 20 deg C, 12 h 2: 60 percent / HCl / H2O; acetone / 0.5 h / 20 °C 3: 85 percent / LiAlH4 / diethyl ether / 5 h / 20 °C 4: 85 percent / pyridine / benzene / 0.67 h / 20 °C View Scheme
参考文献
Odinokov, V. N.; Akhmetova, V. R.; Khasanov, Kh. D.; Abduvakhabov, A. A.; Tolstikov, O. A.
Chemistry of Natural Compounds, 1991 , vol. 27, # 4 p. 497 - 499
Khimiya Prirodnykh Soedinenii, 1991 , # 4 p. 568 - 571
反应条件
1: NaNH2 / tetrahydrofuran / 3 h 2: tetrahydrofuran / 0 - 20 °C 4: H2, quinoline / Pd-BaSO4 / hexane 5: 98 percent / NaOAc / 0 °C View Scheme
参考文献
Vinczer, Peter; Juvancz, Zoltan; Novak, Lajos; Szantay, Csaba
Acta Chimica Hungarica, 1988 , vol. 125, # 6 p. 797 - 820
反应条件
1: 1.) NaH, DMSO / 1.) 70-80 deg C, 15 min, then room t., 20 min, 2.) DMSO, room t., 1.5 h 2: 58 percent / pTs-OH / methanol / 2 h / 0 °C View Scheme
参考文献
Sugiura; Naito; Yamaura; Fukaya; Yokoyama
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 4 p. 1039 - 1043
反应条件
1: n-pentyltriphenylphosphonium bromide With potassium tert-butylate in toluene Dehydrobromination; Heating; 2: 5-hydroxyvaleraldehyde in toluene T=25°C; Wittig reaction; 2 h;
参考文献
Vinczer, Peter; Novak, Lajos; Szantay, Csaba
Organic Preparations and Procedures International, 1991 , vol. 23, # 4 p. 443 - 447
反应条件
1: (i) nBuLi, DMSO, (ii) /BRN= 741880/ 2: SeO2 / ethanol View Scheme
参考文献
Bhalerao,U.T.; Rapoport,H.
Journal of the American Chemical Society, 1971 , vol. 93, p. 4835 - 4840
反应条件
methyllithium 1.) ether, 0.75 h, 25 deg C; 2.) 5 deg C, 3 h;
参考文献
Shen, Yanchang; Qiu, Weiming
Journal of Fluorine Chemistry, 1988 , vol. 38, p. 175 - 182
反应条件
1: PhLi 2: H2 / Pd-C View Scheme
参考文献
Kosower,E.M.; Miyadera,T.
Journal of Medicinal Chemistry, 1972 , vol. 15, p. 339 - 340
