反应条件
1: 98 percent / TsOH / benzene / 20 h / Heating 2: 1.) Mg, I2 / 1.) anhydrous THF, 4 h, 60 deg C, 2.) THF 3: 97 percent / H2O, 10percent HCl / methanol / 1 h / Ambient temperature 4: 1.) t-BuOK / 1.) anhydrous THF, 30 min, RT, 2.) THF, RT, 24 h 5: 58 percent / LAH / diethyl ether / 6 h / -78 °C 6: 1.) (L)-(+)-diisopropyl tartrate, 4A sieves, Ti(OiPr)4, t-BuOOH / 1.) CH2Cl2, 1 h, 2.) CH2Cl2, -20 deg C, 3.5 h 7: H2, 1M NaOH / 10percent Pd/C / ethanol / Ambient temperature 8: LiBr, NCS / methanol / Ambient temperature 9: TsOH / Ambient temperature 10: 1.) t-BuLi / 1.) Et2O, hexane, -78 deg C, 2.) Et2O, hexane, RT 11: H2O, 5percent HCl / methanol / RT, then -20 deg C 12: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / Ambient temperature View Scheme
参考文献
Hamon, David P.G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron, 1995 , vol. 51, # 46 p. 12645 - 12660
