1: 6-chloro-9H-purin-2-ylamine With potassium carbonate in N,N-dimethyl-formamide T=60 - 65°C; 1 h; 2: ethylene dibromide in N,N-dimethyl-formamide 24 h; Reflux;

potassium carbonate in N,N-dimethyl-formamide T=20°C; Alkylation; 48 h;

triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=70°C; Mitsunobu coupling reaction; 12 h; Inert atmosphere;

1: trichlorophosphate / N,N-dimethyl-formamide / 6 h / 0 °C / Reflux 2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere View Scheme

1: potassium carbonate / dimethyl sulfoxide / 4 h / 40 - 50 °C 2: palladium 10 on activated carbon; hydrogen; triethylamine / methanol / 7 h / 55 °C 3: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C View Scheme

1: potassium carbonate / dimethyl sulfoxide / 4 h / 40 - 50 °C 2: palladium 10 on activated carbon; hydrogen; triethylamine / methanol / 7 h / 55 °C 3: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C 4: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 12 h / 20 °C View Scheme

1: potassium carbonate / dimethyl sulfoxide / 4 h / 40 - 50 °C 2: palladium 10 on activated carbon; hydrogen; triethylamine / methanol / 7 h / 55 °C View Scheme