2,5-二氯-3-硝基吡啶合成路线 （共 16 条）
反应条件
1: With hydrogenchloride in water T=-10°C; 2: With sodium nitrite in water T=0°C; 2 h; 3: With sodium hydroxide in water T=-10 - 0°C; pH=9;
参考文献
GLAXO GROUP LIMTED
Patent: WO2007/67875 A2, 2007 ;
Location in patent: Page/Page column 15 ;
WO 2007/067875 A2
反应条件
phosphorus pentachloride; trichlorophosphate
参考文献
Journal of the Chemical Society, , p. 2042,2044
反应条件
in hexane; N,N-dimethyl-formamide; toluene
参考文献
Ciba-Geigy Corporation
Patent: US5274100 A1, 1993 ;
反应条件
1: 17 percent / SO3; H2SO4; HNO3 / 3 h / 20 °C 2: PCl5 / various solvent(s) / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 10 p. 2625 - 2637
反应条件
hydrogenchloride; sodium nitrite T=-15°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 10 p. 2625 - 2637
参考文献
Heilmann, Dieter; Siehr, Ilona; Beerbalk, Hans-Dieter; Kempter, Gerhard; Koeppel, Hubert
Zeitschrift fuer Chemie (Stuttgart, Germany), 1986 , vol. 26, # 3 p. 99
反应条件
in 1-methyl-pyrrolidin-2-one T=160°C; 0.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/97805 A1, 2005 ;
Location in patent: Page/Page column 57-58 ;
反应条件
in methanol 7 h; Reflux;
参考文献
ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; GOMEZ CASTILLO, Elena; BACH TANA, Jordi
Patent: WO2012/160030 A1, 2012 ;
Location in patent: Page/Page column 65 ;
反应条件
hydrogen in tetrahydrofuran; water T=120°C; P=37503.8 Torr; 15 h; chemoselective reaction;
参考文献
Jagadeesh, Rajenahally V.; Surkus, Annette-Enrica; Junge, Henrik; Pohl, Marga-Martina; Radnik, Joerg; Rabeah, Jabor; Huan, Heming; Schunemann, Volker; Brueckner, Angelika; Beller, Matthias
Science, 2013 , vol. 342, # 6162 p. 1073 - 1076
反应条件
1: With sodium hydride in tetrahydrofuran; mineral oil T=20°C; 3.83333 h; Inert atmosphere; 2: With hydrogenchloride; water 12.5 h; Reflux; 3: With sodium carbonate pH=9;
参考文献
GLAXOSMITHKLINE LLC; BOBKO, Mark, A.; DARCY, Michael, G.; EVANS, Karen, A.; FAITG, Thomas, H.; KAURA, Arun, Chandar; PENG, Xin; SARPONG, Martha, A.; SEEFELD, Mark, A.; SU, Dai-shi
Patent: WO2012/149102 A1, 2012 ;
Location in patent: Page/Page column 47 ;
WO 2012/149102 A1
