1-(2-氨基-5-氟苯基)-2,2,2-三氟乙酮合成路线 （共 5 条）
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; ethylene glycol dimethyl ether; hexane
参考文献
Bristol-Myers Squibb Pharma Company
Patent: US6462037 B1, 2002 ;
反应条件
hydrogenchloride; n-butyllithium; sodium carbonate in tetrahydrofuran; ethylene glycol dimethyl ether; hexane
参考文献
Dupont Pharmaceuticals Company
Patent: US6140320 A1, 2000 ;
反应条件
hydrogenchloride in ethylene glycol dimethyl ether amide cleavage; 2 h; Heating;
参考文献
Patel, Mona; Ko, Soo S.; McHugh Jr., Robert J.; Markwalder, Jay A.; Srivastava, Anurag S.; Cordova, Beverly C.; Klabe, Ronald M.; Erickson-Viitanen, Susan; Trainor, George L.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2805 - 2810
反应条件
1.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 - 0 °C 1.2: tetrahydrofuran 2.1: 6 N aq. HCl / 1,2-dimethoxy-ethane / 2 h / Heating View Scheme
参考文献
Patel, Mona; Ko, Soo S.; McHugh Jr., Robert J.; Markwalder, Jay A.; Srivastava, Anurag S.; Cordova, Beverly C.; Klabe, Ronald M.; Erickson-Viitanen, Susan; Trainor, George L.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2805 - 2810
反应条件
1.1: TEA / CH2Cl2 / 3 h / 0 - 25 °C 2.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 - 0 °C 2.2: tetrahydrofuran 3.1: 6 N aq. HCl / 1,2-dimethoxy-ethane / 2 h / Heating View Scheme
参考文献
Patel, Mona; Ko, Soo S.; McHugh Jr., Robert J.; Markwalder, Jay A.; Srivastava, Anurag S.; Cordova, Beverly C.; Klabe, Ronald M.; Erickson-Viitanen, Susan; Trainor, George L.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2805 - 2810
