4-甲基-4'-硝基联苯合成路线 （共 71 条）
反应条件
para-nitro iodo-benzene; (Ph3P)2Pd(Ph)(I) in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=70°C; 0.3 h;
参考文献
Bumagin, N. A.; Bumagina, I. G.; Beletskaya, I. P.
Doklady Chemistry, 1983 , vol. 272, p. 333 - 336
Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 272, # 6 p. 1384 - 1388
反应条件
1: (4-methylphenyl)trichlorogermane With ammonium hydroxide
T=20°C; 1 h;
2: para-nitro iodo-benzene With sodium hydroxide; palladium diacetate in 1,4-dioxane; water
1.5 h; Heating; Further stages.;
参考文献
Endo, Mayuko; Fugami, Keigo; Enokido, Tatsuki; Sano, Hiroshi; Kosugi, Masanori
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 7 p. 1025 - 1027
反应条件
1: (4-methylphenyl)trichlorogermane With ammonium hydroxide
T=20°C; 1 h;
2: 1-bromo-4-nitro-benzene With sodium hydroxide; palladium diacetate in 1,4-dioxane; water
4 h; Heating; Further stages.;
参考文献
Endo, Mayuko; Fugami, Keigo; Enokido, Tatsuki; Sano, Hiroshi; Kosugi, Masanori
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 7 p. 1025 - 1027
反应条件
MCM-41-supported mercapto palladium(0) complex in water; N,N-dimethyl-formamide
T=60°C; Stille coupling; 4 h;
参考文献
Zhao, Hong; Zheng, Guomin; Hao, Wenyan; Cai, Mingzhong
Applied Organometallic Chemistry, 2010 , vol. 24, # 2 p. 92 - 98
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in neat (no solvent)
T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; cesium fluoride in N,N-dimethyl-formamide
T=20°C; Stille coupling; 18 h;
参考文献
Grelaud, Guillaume; Tohme, Ayham; Argouarch, Gilles; Roisnel, Thierry; Paul, Frederic
New Journal of Chemistry, 2011 , vol. 35, # 12 p. 2740 - 2742
反应条件
palladium diacetate; potassium carbonate in methanol
T=60°C; Suzuki Coupling; Inert atmosphere;
参考文献
Liu, Jin-Biao; Yan, Hui; Chen, Hui-Xuan; Luo, Yu; Weng, Jiang; Lu, Gui
Chemical Communications, 2013 , vol. 49, # 46 p. 5268 - 5270
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in neat (no solvent)
T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
sodium hydroxide
T=0°C;
参考文献
Gomberg; Pernert
Journal of the American Chemical Society, 1926 , vol. 48, p. 1381
反应条件
copper in N,N-dimethyl-formamide
6 h; Heating;
参考文献
Shudo, Koichi; Ohta, Toshiharu; Okamoto, Toshihiko
Journal of the American Chemical Society, 1981 , vol. 103, # 3 p. 645 - 653
