4-甲基-4'-硝基联苯合成路线 （共 71 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); copper(I) bromide dimethylsulfide complex; trifuran-2-yl-phosphane in tetrahydrofuran
Stille coupling; Heating;
参考文献
Dubbaka, Srinivas Reddy; Vogel, Pierre
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15292 - 15293
反应条件
palladium 10 on activated carbon in methanol
Suzuki-Miyaura cross-coupling; RefluxUnder air;
参考文献
Hanna Jr., James M.; Varnedoe, Lee S.; Angel, Brad D.; McClellan, Joshua L.
Letters in Organic Chemistry, 2010 , vol. 7, # 1 p. 1 - 6
反应条件
1.1: t-BuLi / pentane; diethyl ether / 1 h / -78 °C
1.2: pentane; diethyl ether / 2 h / -100 - 20 °C
2.1: 71 percent / Ba(OH)2*8H2O / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 10 h / Heating
View Scheme
参考文献
Klein, Markus; Erdinger, Lothar; Boche, Gernot
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2000 , vol. 467, # 1 p. 69 - 82
反应条件
(Ph3P)2Pd(Ph)(I) in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=70°C; 0.3 h;
参考文献
Bumagin, N. A.; Bumagina, I. G.; Beletskaya, I. P.
Doklady Chemistry, 1983 , vol. 272, p. 333 - 336
Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 272, # 6 p. 1384 - 1388
反应条件
potassium phosphate in 1,4-dioxane
T=110°C; Suzuki-Miyaura coupling; 18 h; Inert atmosphere;
参考文献
Chow, Wing Kin; Yuen, On Ying; So, Chau Ming; Wong, Wing Tak; Kwong, Fuk Yee
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3543 - 3548
反应条件
palladium diacetate in water; acetonitrile
T=20°C; 2 h;
参考文献
Bumagin, N. A.; Sukhomlinova, L. I.; Tolstaya, T. P.; Beletskaya, I. P.
Russian Journal of Organic Chemistry, 1994 , vol. 30, # 10 p. 1605 - 1609
Zhurnal Organicheskoi Khimii, 1994 , vol. 30, # 10 p. 1524 - 1527
反应条件
trifluoroacetic acid
T=65 - 70°C; 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Patrick, Timothy B.; Willaredt, Richard P.; DeGonia, David J.
Journal of Organic Chemistry, 1985 , vol. 50, # 13 p. 2232 - 2235
参考文献
Grieve; Hey
Journal of the Chemical Society, 1932 , p. 1888,1891
反应条件
1: sodium sulfate / tetrahydrofuran / 24 h / 20 °C / |Schlenk technique; |Inert atmosphere
2: palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium carbonate / neat (no solvent) / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); 2-(2-methoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; potassium acetate / 1,4-dioxane / 24 h / 110 °C / Inert atmosphere
2: potassium phosphate / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere
View Scheme
参考文献
Chow, Wing Kin; Yuen, On Ying; So, Chau Ming; Wong, Wing Tak; Kwong, Fuk Yee
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3543 - 3548
