4-甲氧基-4'-硝基联苯合成路线 （共 81 条）
反应条件
1: 4-MeOC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran T=25°C; 0.25 h; Inert atmosphere; 2: 1-bromo-4-nitro-benzene With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Dalton Transactions, , vol. 40, # 35 p. 8996 - 9003
反应条件
in various solvent(s) 1 h; Ambient temperature;
参考文献
Effenberger, Franz; Koch, Markus; Streicher, Willi
Chemische Berichte, 1991 , vol. 124, # 1 p. 163 - 173
反应条件
ammonium cerium(IV) nitrate in acetonitrile; benzene 2 h; Ambient temperature; Yield given. Title compound not separated from byproducts;
参考文献
Arai, Noriyoshi; Narasaka, Koichi
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 6 p. 1707 - 1714
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide T=90°C; Suzuki-Miyaura Coupling; 24 h; Schlenk technique;
参考文献
Journal of the American Chemical Society, , vol. 134, # 49 p. 19997 - 20000
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Qiu, Di; Meng, He; Jin, Liang; Wang, Shuai; Tang, Shengbo; Wang, Xi; Mo, Fanyang; Zhang, Yan; Wang, Jianbo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11581 - 11584
Angew. Chem., 2013 , vol. 125, # 44 p. 11795 - 11798
反应条件
in N,N-dimethyl-formamide T=60°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 53, # 29 p. 10009 - 10018
反应条件
1.1: potassium methanolate / ethylene glycol dimethyl ether / 0.17 h / 30 °C / |Inert atmosphere 1.2: 1 h / 30 °C 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C / |Schlenk technique View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 49 p. 19997 - 20000
反应条件
1.1: potassium methanolate / ethylene glycol dimethyl ether / 0.17 h / 30 °C / |Inert atmosphere 1.2: 1 h / 30 °C 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C / |Schlenk technique View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 49 p. 19997 - 20000
反应条件
1: tert.-butylnitrite; toluene-4-sulfonic acid / 1,2-dichloro-ethane / 4 h / 0 °C / |Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0) / toluene / 12 h / 110 °C / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 44 p. 11581 - 11584
Angew. Chem., , vol. 125, # 44 p. 11795 - 11798
反应条件
1: 54 percent / dimethylformamide / 2 h / 95 °C 2: dimethylformamide / 80 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 29 p. 10009 - 10018
