4,4,4-三氟-3-苯基-丁2-烯酸合成路线 （共 3 条）
反应条件
potassium carbonate in methanol; water T=60°C; 2 h;
参考文献
Carceller, Elena; Merlos, Manuel; Giral, Marta; Almansa, Carmen; Bartroli, Javier; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2984 - 2997
反应条件
potassium hydroxide in methanol T=0°C; 3 h;
参考文献
Ohno, Nobuhiro; Fukamiya, Narihiko; Okano, Masayoshi; Tagahara, Kiyoshi; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1489 - 1495
反应条件
1: 1.) butyllithium / 1.) Et2O, hexane, RT, 30 min, 2.) Et2O, RT, 17 h 2: 63.8 percent / 10percent KOH / methanol / 3 h / 0 °C View Scheme
参考文献
Ohno, Nobuhiro; Fukamiya, Narihiko; Okano, Masayoshi; Tagahara, Kiyoshi; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1489 - 1495
