4-溴-1-甲基吡啶-2-酮合成路线 （共 6 条）
反应条件
1: 2-hydroxy-4-bromopyridine With sodium hydride in tetrahydrofuran T=20°C; 0.0833333 h; 2: methyl iodide in tetrahydrofuran T=20°C;
参考文献
PROLYSIS LTD
Patent: WO2009/74812 A1, 2009 ;
Location in patent: Page/Page column 16 ;
WO 2009/074812 A1
反应条件
sulfuric acid; potassium carbonate in water; acetone
参考文献
WASHINGTON UNIVERSITY
Patent: US2011/311447 A1, 2011 ;
反应条件
1: 4-bromo-pyridin-2-yl-amine With sulfuric acid; sodium nitrite T=0 - 5°C; 2 h; 2: methyl iodide With potassium carbonate in acetone T=80°C; 4 h; Sealed tube;
参考文献
Li, Junfeng; Zhang, Xiang; Zhang, Zhanbin; Padakanti, Prashanth K.; Jin, Hongjun; Cui, Jinquan; Li, Aixiao; Zeng, Dexing; Rath, Nigam P.; Flores, Hubert; Perlmutter, Joel S.; Parsons, Stanley M.; Tu, Zhude
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6216 - 6233
反应条件
potassium carbonate in dimethyl sulfoxide T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 23 p. 7076 - 7080
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -18 - 20 °C / Inert atmosphere 1.2: 2 h / -20 °C 2.1: hydrogenchloride; water / tetrahydrofuran / 6 h / 5 - 20 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; TAN, Zhulin
Patent: WO2011/149822 A1, 2011 ;
反应条件
1: With potassium acetate in 1,4-dioxane 0.25 h; 2: With tri-cyclo-hexyl-phosphine; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane T=80 - 85°C; 3.25 h;
参考文献
PROLYSIS LTD
Patent: WO2009/74812 A1, 2009 ;
Location in patent: Page/Page column 73 ;
WO 2009/074812 A1
