4-(4,4,5,5-四甲基-1,3,2-二氧杂硼烷-2-基)氟苯合成路线 （共 26 条）
反应条件
1: C10H14BFN2 With magnesium bis(2,2,6,6-tetramethylpiperamide) in tetrahydro-4H-pyran; hexane RefluxInert atmosphereCooling; 2: With iodine in tetrahydro-4H-pyran; hexane T=20°C; Inert atmosphereCooling; 3: 2,3-dimethylbutane-2,3-diol Further stages;
参考文献
Chemistry - A European Journal, , vol. 17, # 29 p. 8005 - 8008
反应条件
in water; benzene 1 h; Inert atmosphereReflux;
参考文献
Carrow, Brad P.; Hartwig, John F.
Journal of the American Chemical Society, 2011 , vol. 133, # 7 p. 2116 - 2119
反应条件
1.1: tetrafluoroboric acid / water / 0.17 h / 0 °C 1.2: 1 h / 0 °C 1.3: 2.5 h / 20 °C / |Inert atmosphere 2.1: diethyl ether / 4 h / 20 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 6 p. 1083 - 1088
反应条件
(CF3SO2)2NLi in tetrahydrofuran Electrolysis; electrolysis with Mg anode under inert atm. at room temp. at 0.15 A/dm**2; after electrolysis, solvent evapd. under vac.; slowly hydrolysed at 0°C with soln. of H2SO4 until pH 5; purified by column chromy. on silica gel (pentane/ether);
参考文献
Electrochimica Acta, , vol. 50, # 25-26 SPEC. ISS. p. 4897 - 4901
反应条件
caesium carbonate in methanol 60 h; RefluxInert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 28 p. 6263 - 6266
反应条件
1.1: toluene / Inert atmosphere; Heating 2.1: magnesium bis(2,2,6,6-tetramethylpiperamide) / tetrahydro-4H-pyran; hexane / Reflux; Inert atmosphere; Cooling 2.2: 20 °C / Inert atmosphere; Cooling View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 29 p. 8005 - 8008
反应条件
C2F3O2(1-)*C21H34IrN4(1+) T=180°C; 0.5 h; Microwave irradiationNeat (no solvent);
参考文献
Green Chemistry, , vol. 11, # 10 p. 1610 - 1617
反应条件
potassium fluoride in N,N-dimethyl-formamide T=50°C; Inert atmosphere;
参考文献
Litvinas, Nichole D.; Fier, Patrick S.; Hartwig, John F.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 536 - 539
反应条件
1: With potassium hydrogen difluoride in methanol T=20°C; 0.25 h; 2: With lithium hydroxide in acetonitrile T=20°C; 20 h;
参考文献
Yuen, Alexander K.L.; Hutton, Craig A.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7899 - 7903
反应条件
1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate; C10H18CuN2(1+)*CF3O3S(1-); silver fluoride in tetrahydrofuran T=50°C; 18 h; Inert atmosphere;
参考文献
Fier, Patrick S.; Luo, Jingwei; Hartwig, John F.
Journal of the American Chemical Society, 2013 , vol. 135, # 7 p. 2552 - 2559
