1: 2,5-dibromo-pyridine With n-butyllithium; tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 2: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether

magnesium sulfate in diethyl ether T=20°C; 16 h;

1: 2-bromo-5-iodopyridine With n-butyllithium; tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 2: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether

1.1: 75 percent / periodic acid dihydrate; iodine; sulfuric acid / acetic acid; H2O / 4 h / 80 °C 2.1: 77 percent / hydrobromic acid; sodium nitrite; bromine / H2O / -5 - 20 °C 3.1: nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C 3.2: 10 percent / acetic acid / diethyl ether View Scheme

1.1: 77 percent / hydrobromic acid; sodium nitrite; bromine / H2O / -5 - 20 °C 2.1: nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C 2.2: 10 percent / acetic acid / diethyl ether View Scheme

dihydrogen peroxide in dichloromethane; water T=20°C; 20 h;

potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=65°C;