3,4,5-三甲氧基苯硼酸频那醇酯合成路线 （共 12 条）
反应条件
1: With bis(dibenzylideneacetone)-palladium(0) in methanol T=20°C; 0.166667 h; Inert atmosphereGlovebox; 2: With potassium fluoride in methanol T=20°C; 24 h; Inert atmosphereGlovebox;
参考文献
Robbins, Daniel W.; Hartwig, John F.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 3 p. 933 - 937
Angew. Chem., 2012 , vol. 125, # 3 p. 967 - 971,5
反应条件
1: With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane
T=80°C; 18 h;
2: 5-bromo-1,2,3-trimethoxy-benzene; 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane in 1,4-dioxane
T=80°C; 18 h;
参考文献
Commonwealth Scientific and Industrial Research Organisation
Patent: US6680401 B1, 2004 ;
Location in patent: Page column 59 ;
反应条件
1: tBuCH2CH2B(H)NiPr2; 3,4,5-(MeO)3C6H2N2BF4 With biscyclopentadienyliron(II) in acetonitrile
T=20°C; 2.5 h;
2: With methanol in acetonitrile
T=0 - 20°C; 1 h;
3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile
T=20°C; 4 h; Reagent/catalyst;
参考文献
UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel
Patent: WO2014/9169 A1, 2014 ;
Location in patent: Page/Page column 56 ;
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II); 1,3-bis-(diphenylphosphino)propane; triethylamine in toluene
T=100°C; 18 h; Inert atmosphere;
参考文献
Rosen, Brad M.; Huang, Chenghong; Percec, Virgil
Organic Letters, 2008 , vol. 10, # 12 p. 2597 - 2600
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in dimethyl sulfoxide
T=80°C; 24 h; Inert atmosphere;
参考文献
Gerbino, Dario C.; Mandolesi, Sandra D.; Schmalz, Hans-Guenther; Podesta, Julio C.
European Journal of Organic Chemistry, 2009 , # 23 p. 3964 - 3972
反应条件
1: 5-bromo-1,2,3-trimethoxy-benzene With iodine; magnesium in tetrahydrofuran
0.666667 h; Inert atmosphereReflux;
2: With boric acid trimethyl ester in tetrahydrofuran
T=-78 - 25°C;
3: 2,3-dimethylbutane-2,3-diol With acetic acid in tetrahydrofuran
T=20°C; 4 h;
参考文献
Gerbino, Dario C.; Mandolesi, Sandra D.; Schmalz, Hans-Guenther; Podesta, Julio C.
European Journal of Organic Chemistry, 2009 , # 23 p. 3964 - 3972
反应条件
[Ir2(OMe)2(1,5-cyclooctadiene)2]; 3,4,7,8-tetra-methyl-1,10-phenanthroline in tetrahydrofuran
T=80°C; 2.5 h; GloveboxInert atmosphere; Reagent/catalyst;
参考文献
Preshlock, Sean M.; Ghaffari, Behnaz; Maligres, Peter E.; Krska, Shane W.; Maleczka, Robert E.; Smith, Milton R.
Journal of the American Chemical Society, 2013 , vol. 135, # 20 p. 7572 - 7582
反应条件
[Ir2(OMe)2(1,5-cyclooctadiene)2]; 3,4,7,8-tetra-methyl-1,10-phenanthroline in tetrahydrofuran
T=80°C; 2.5 h; GloveboxInert atmosphere;
参考文献
Preshlock, Sean M.; Ghaffari, Behnaz; Maligres, Peter E.; Krska, Shane W.; Maleczka, Robert E.; Smith, Milton R.
Journal of the American Chemical Society, 2013 , vol. 135, # 20 p. 7572 - 7582
反应条件
in diethyl ether
T=20°C; 4 h; Inert atmosphere;
参考文献
Marciasini, Ludovic D.; Vaultier, Michel; Pucheault, Mathieu
Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1702 - 1705
反应条件
1: 5-bromo-1,2,3-trimethoxy-benzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h; Inert atmosphere;
2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane
T=-78 - 20°C; Inert atmosphere;
参考文献
Yasuda, Takuma; Shimizu, Tomohiro; Liu, Feng; Ungar, Goran; Kato, Takashi
Journal of the American Chemical Society, 2011 , vol. 133, # 34 p. 13437 - 13444
