(S)-1-(2-氯乙酰基)吡咯烷-2-羧酰胺合成路线 （共 8 条）
反应条件
1: With dicyclohexyl-carbodiimide in dichloromethane T=20°C; 5 h; Cooling with ice; 2: With ammonium carbamate in dichloromethane T=20°C; 6 h;
参考文献
Xu, Xiaojian; Guo, Jianwei; Su, Qiang; Zhong, Xing
Asian Journal of Chemistry, 2013 , vol. 25, # 13 p. 7557 - 7560
反应条件
potassium carbonate in tetrahydrofuran
参考文献
Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Dunning, Beth E.; Mangold, Bonnie L.; Mone, Manisha D.; Russell, Mary E.; Weldon, Stephen C.; Hughes, Thomas E.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2362 - 2365
反应条件
1.1: chloro-trimethyl-silane / acetonitrile / 1 h / 50 °C 1.2: 20 °C 2.1: thionyl chloride / dichloromethane / 1.17 h / 0 - 20 °C 2.2: 2 h View Scheme
参考文献
Xu, Xiaojian; Guo, Jianwei; Su, Qiang; Zhong, Xing
Asian Journal of Chemistry, 2013 , vol. 25, # 13 p. 7557 - 7560
反应条件
1: ammonium hydroxide 2: tetrahydrofuran View Scheme
参考文献
Peng, Jun; Feng, Yue; Tao, Zhu; Chen, Yingjie; Hu, Xiangnan
Letters in Organic Chemistry, 2013 , vol. 10, # 3 p. 159 - 163
反应条件
1: (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxamide With trifluoroacetic anhydride in tetrahydrofuran T=20°C; 2 h; Cooling with ice; 2: 3-hydroxytricyclo[3.3.1.13.7 ]decan-1-amine With potassium carbonate; potassium iodide in tetrahydrofuran T=40°C; 8.5 h; Reflux; Time;
参考文献
Asian Journal of Chemistry, , vol. 25, # 13 p. 7557 - 7560
反应条件
1: 7.82 g / trifluoroacetic anhydride / tetrahydrofuran / 1 h / 20 °C 2: K2CO3 / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 13 p. 2774 - 2789
反应条件
2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide T=35 - 48°C; 4 h;
参考文献
Peng, Jun; Feng, Yue; Tao, Zhu; Chen, Yingjie; Hu, Xiangnan
Letters in Organic Chemistry, 2013 , vol. 10, # 3 p. 159 - 163
反应条件
1: 7.82 g / trifluoroacetic anhydride / tetrahydrofuran / 1 h / 20 °C
2: K2CO3 / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Dunning, Beth E.; Mangold, Bonnie L.; Mone, Manisha D.; Russell, Mary E.; Weldon, Stephen C.; Hughes, Thomas E.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2362 - 2365
