溴伏克辛合成路线

参考文献

American Home Products Corporation
Patent: US2002/68735 A1, 2002 ;
US 20020068735 A1

52727-57-85-溴氨基苯甲酸甲酯

21440-97-1溴伏克辛

参考文献

Journal of Medicinal Chemistry, , vol. 48, # 16 p. 5092 - 5095

60811-21-43-氯-4-氟溴苯+

21440-97-1溴伏克辛

304854-45-36-(3-氯-4-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮

参考文献

Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6444668 B1, 2002 ;

21440-97-1溴伏克辛

304854-45-36-(3-氯-4-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮

参考文献

Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382

3900-89-82-氯苯基硼酸+

21440-97-1溴伏克辛

304854-37-36-(2-氯苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮

参考文献

Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6444668 B1, 2002 ;

21440-97-1溴伏克辛

304854-07-75-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁英-6-基)-2-氟苯甲腈

参考文献

Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382

21440-97-1溴伏克辛

304853-30-33-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁嗪)-5-氟苯甲腈

参考文献

Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382

10365-98-73-甲氧基苯硼酸+

21440-97-1溴伏克辛

304854-36-26-(3-甲氧基苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮

参考文献

Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6444668 B1, 2002 ;

10365-98-73-甲氧基苯硼酸+

21440-97-1溴伏克辛

304854-36-26-(3-甲氧基苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮

参考文献

Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6436929 B1, 2002 ;
US 6436929 B1

21440-97-1溴伏克辛

304854-09-96-(3-氯-5-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮

参考文献

Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382