1: 6-bromo-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; hexane T=20°C; Further stages.;
参考文献
Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6436929 B1, 2002 ;
US 6436929 B1
