4-氯-7-(2-氯乙氧基)-6-甲氧基-3-喹啉甲腈合成路线 （共 7 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane 2.5 h; Heating / reflux;
参考文献
Wyeth Holdings Corporation
Patent: EP1117659 B1, 2003 ;
Location in patent: Page 59 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=0°C; Mitsunobu conditions; 0.25 h;
参考文献
Boschelli; Ye; Wang; Dutia; Johnson; Wu; Miller; Powell; Yaczko; Young; Tischler; Arndt; Discafani; Etienne; Gibbons; Grod; Lucas; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3965 - 3977
反应条件
sodium hydroxide in N-methyl-acetamide; dichloromethane
参考文献
American Cyanamid Company
Patent: US6288082 B1, 2001 ;
反应条件
1.1: K2CO3; (C8H17)3N(CH3)Cl / acetone / Heating 2.1: HNO3; AcOH / 50 °C 3.1: Fe; NH4Cl / methanol / Heating 4.1: Heating 5.1: tetrahydrofuran / -78 °C 5.2: AcOH / 20 °C 6.1: POCl3 / Heating View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1.1: HNO3; AcOH / 50 °C 2.1: Fe; NH4Cl / methanol / Heating 3.1: Heating 4.1: tetrahydrofuran / -78 °C 4.2: AcOH / 20 °C 5.1: POCl3 / Heating View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1.1: Heating 2.1: tetrahydrofuran / -78 °C 2.2: AcOH / 20 °C 3.1: POCl3 / Heating View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1.1: Fe; NH4Cl / methanol / Heating 2.1: Heating 3.1: tetrahydrofuran / -78 °C 3.2: AcOH / 20 °C 4.1: POCl3 / Heating View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
