6-甲基-3-氮杂双环[4.1.0]庚烷-4-酮合成路线 （共 3 条）
反应条件
sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; sodium fluoride in hexane; dichloromethane; water; ethyl acetate
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US6110930 A1, 2000 ;
反应条件
trimethylaluminum in hexane; dichloromethane
T=0 - 20°C; Simmons-Smith reaction;
参考文献
Kawanaka, Yasufumi; Kobayashi, Kaoru; Kusuda, Shinya; Tatsumi, Tadashi; Murota, Masayuki; Nishiyama, Toshihiko; Hisaichi, Katsuya; Fujii, Atsuko; Hirai, Keisuke; Naka, Masao; Komeno, Masaharu; Nakai, Hisao; Toda, Masaaki
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 3 p. 277 - 288
反应条件
1: 84 percent / Li; liquid NH3 / tetrahydrofuran; ethanol / 1.5 h / -78 °C
2: 35 percent / AlMe3 / CH2Cl2; hexane / 0 - 20 °C
View Scheme
参考文献
Kawanaka, Yasufumi; Kobayashi, Kaoru; Kusuda, Shinya; Tatsumi, Tadashi; Murota, Masayuki; Nishiyama, Toshihiko; Hisaichi, Katsuya; Fujii, Atsuko; Hirai, Keisuke; Naka, Masao; Komeno, Masaharu; Nakai, Hisao; Toda, Masaaki
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 3 p. 277 - 288
