2-甲基-1-萘基溴化镁合成路线 （共 19 条）
反应条件
1: 87 percent / benzene; diethyl ether / 1.) 2 h, room temperature, 2.) 3 h, reflux 2: N-bromosuccinimide (NBS), benzoyl peroxide (BPO) / CCl4 / 8 h / Heating 3: 1.) AcOK; 2.) 2 N HCl / 1.) AcOH, 8 h, reflux; 2.) reflux, 30 min 4: 97 percent / KMnO4 / acetone; H2O / 1.5 h / Heating View Scheme
参考文献
Oi; Matsunaga; Hattori; Miyano
Synthesis, 1993 , # 9 p. 895 - 899
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 5.7 g / aq. HCl / petroleum ether / 3 h / 20 °C View Scheme
参考文献
Clews, John; Curtis, Anthony D.M.; Malkin, Hugh
Tetrahedron, 2000 , vol. 56, # 44 p. 8735 - 8746
反应条件
NiCl2((PPh3)P)2 in diethyl ether; benzene 3 h; Heating;
参考文献
Miyano, Sotaro; Okada, Shin-ichi; Suzuki, Toshiyuki; Handa, Shigeru; Hashimoto, Harukichi
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, p. 2044 - 2046
反应条件
iron(III) chloride; 1,2-dichloro-ethane in diethyl ether 12 h; Heating;
参考文献
Nagano, Takashi; Hayashi, Tamio
Organic Letters, 2005 , vol. 7, # 3 p. 491 - 493
反应条件
hydrogenchloride in water; toluene
参考文献
Hoechst Aktiengesellschaft
Patent: US5510554 A1, 1996 ;
反应条件
C46H55ClFeN3Pd; lithium chloride in tetrahydrofuran
T=60°C; Kumada coupling reaction; 24 h; Inert atmosphere;
参考文献
Ren, Gerui; Cui, Xiuling; Wu, Yangjie
European Journal of Organic Chemistry, 2010 , # 12 p. 2372 - 2378
反应条件
1: diethyl ether / Erhitzen des Reaktionsprodukts in Xylol unter Zusatz von Jod
2: sulfur / 250 °C
View Scheme
参考文献
Huisgen; Sorge
Justus Liebigs Annalen der Chemie, 1950 , vol. 566, p. 162,179
反应条件
1: 82 percent / NiCl2(PPh3)2 / diethyl ether; benzene / 3 h / Heating
2: NBS, benzoyl peroxide / CCl4 / 3 h / Heating
View Scheme
参考文献
Sugimoto, Akira; Sumida, Ryozo; Tamai, Naoto; Inoue, Hiroo; Otsuji, Yoshio
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 11 p. 3500 - 3504
参考文献
Lawesson
Acta Chemica Scandinavica (1947-1973), 1958 , vol. 12, p. 1,7
