1-氮杂双环[2.2.1]庚烷-3-酮合成路线 （共 7 条）
反应条件
potassium tert-butylate in toluene 2 h; Heating;
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
反应条件
hydrogenchloride; potassium tert-butylate 1.) toluene, reflux, 4 h, 2.) 110 deg C, 8 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 10 p. 2690 - 2697
反应条件
1: 1.) BH3*THF, 2.) aq. K2CO3 / 1.) reflux, 1 h, 2.) reflux, 0.75 h 2: 1.) t-BuOK, 2.) concd HCl / 1.) toluene, reflux, 4 h, 2.) 110 deg C, 8 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 10 p. 2690 - 2697
反应条件
sodium hydroxide in ethanol 12 h;
参考文献
Turchin, K. F.; Yanina, A. D.; Filipenko, T. Ya.; Mikhlina, E. E.; Sheinker, Yu. N.; Yakhtonov, L. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 1039 - 1048
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1248 - 1256
反应条件
potassium tert-butylate in ethylene glycol dimethyl ether; ethanol 1.) -8 deg C, 2 h, 2.) RT, 1 h;
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
反应条件
1: 79 percent / NaOH / ethanol / 1) 5 h, reflux, 2) 16 h, 20 deg C 2: 90 percent / H2 / 5percent Pd/C / aq. HCl; methanol / 20 °C 3: 1.32 g / HCl / 1) reflux, 34 h, 2) 4 deg C, 15 h View Scheme
参考文献
Turchin, K. F.; Yanina, A. D.; Filipenko, T. Ya.; Mikhlina, E. E.; Sheinker, Yu. N.; Yakhtonov, L. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 1039 - 1048
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1248 - 1256
反应条件
1.1: hydrogenchloride / 4 h / Reflux 2.1: potassium carbonate / water; tetrahydrofuran / 0 °C 2.2: 20 h / 20 °C 2.3: pH 4 - 5 View Scheme
参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
US 20110224225 A1
