N,4-二[(1,1-二甲基乙氧基)羰基]-L-苯丙氨酸合成路线 （共 2 条）
反应条件
1: Et3N / dimethylformamide / 48 h / 20 °C 2: 6.2 g / LiOH; LiBr; nBu4NBr / acetonitrile / 20 °C View Scheme
参考文献
Anne, Christine; Turcaud, Serge; Quancard, Jean; Teffo, Franck; Meudal, Herve; Fournie-Zaluski, Marie-Claude; Roques, Bernard P.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 22 p. 4648 - 4656
反应条件
1.1: nBuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 1.2: 72 percent / HMPA / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 2.1: 78 percent / aq. citric acid / tetrahydrofuran / 2 h / 20 °C 3.1: Et3N / dimethylformamide / 48 h / 20 °C 4.1: 6.2 g / LiOH; LiBr; nBu4NBr / acetonitrile / 20 °C View Scheme
参考文献
Anne, Christine; Turcaud, Serge; Quancard, Jean; Teffo, Franck; Meudal, Herve; Fournie-Zaluski, Marie-Claude; Roques, Bernard P.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 22 p. 4648 - 4656
