1.1: NaH / dimethylformamide / 0.5 h / 20 °C 1.2: 80 percent / dimethylformamide / 48 h / 20 °C 2.1: H2SO4; NaNO2 / H2O / 0.33 h / 0 °C 2.2: 77 percent / H2O / 1 h / 120 °C View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
1: dioxane / 1 h / 20 °C 2: NaH / dimethylformamide / 5 h / 20 °C 3: NaH / dimethylformamide / 5 h / 85 °C 4: 91 percent / HCl / acetic acid / 6 h / 60 °C View Scheme
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
1: dioxane / 1 h / 20 °C 2: NaH / dimethylformamide / 5 h / 20 °C 3: NaH / dimethylformamide / 5 h / 85 °C 4: 91 percent / HCl / acetic acid / 6 h / 60 °C 5: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
