二甲基3-甲基邻苯二甲酸酯合成路线 （共 15 条）
反应条件
N-bromosuccinmide in acetonitrile T=70°C; 200W light;
参考文献
CELGENE CORPORATION
Patent: WO2008/33567 A1, 2008 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1: methanol; 3-methyl-phthalic acid anhydride 1 h; Heating / reflux;
2: methyl iodide With sodium hydrogencarbonate in N,N-dimethyl-formamide
T=75°C; 1.5 h;
参考文献
CELGENE CORPORATION
Patent: WO2008/33567 A1, 2008 ;
Location in patent: Page/Page column 40 ;
反应条件
lithium aluminium tetrahydride; titanium tetrachloride; triethylamine
24 h; Ambient temperature;
参考文献
Xing, Yi De; Huang, Nai Zheng
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 140 - 142
反应条件
in ethanol; chloroform
T=12 - 20°C; 1 h;
参考文献
Becker, Hans-Dieter; Ruge, Bernd
Journal of Organic Chemistry, 1980 , vol. 45, # 11 p. 2189 - 2195
反应条件
1: methanol; 3-methyl-phthalic acid anhydride With sulfuric acid
Reflux;
2: diazomethyl-trimethyl-silane in methanol; toluene
参考文献
Hughes, Terry V.; Emanuel, Stuart L.; O'Grady, Harold R.; Connolly, Peter J.; Rugg, Catherine; Fuentes-Pesquera, Angel R.; Karnachi, Prabha; Alexander, Richard; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5130 - 5133
参考文献
Hayashi; Tsuruoka
Nippon Kagaku Kaishi, 1935 , vol. 56, p. 999,1002, 1003
Full Text Show Details
Hayashi et al.
Bulletin of the Chemical Society of Japan, 1936 , vol. 11, p. 186
Chem. Zentralbl., 1936 , vol. 107, # II p. 1720
反应条件
1: (hydrolysis)
View Scheme
参考文献
Jones,E.R.H. et al.
Journal of the Chemical Society, 1960 , p. 341 - 346
参考文献
Jones,E.R.H. et al.
Journal of the Chemical Society, 1960 , p. 341 - 346
参考文献
Traynor, Sean G.; Crowley, Kevin J.; Cocker, Wesley
Journal of Chemical Research, Miniprint, 1981 , # 7 p. 2101 - 2115
反应条件
(i) O2, (ii) NaBH4, MeOH, (iii) /BRN= 607063/; Multistep reaction;
参考文献
Baines,D.A.; Cocker,W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 2232 - 2237
