1,2,3,4-四氢-5,6-二甲氧基-2-氨基萘合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated charcoal in methanol; chloroform
T=20°C; 24 h;
参考文献
Goeksu, Sueleyman; Secen, Hasan; Suetbeyaz, Yasar
Helvetica Chimica Acta, 2006 , vol. 89, # 2 p. 270 - 273
反应条件
1: diphenylphosphoryl azide; Et3N / benzene / 6 h / Heating
2: benzene / 30 h / Heating
3: 95 percent / H2 / Pd/C / CHCl3; methanol / 24 h / 20 °C
View Scheme
参考文献
Goeksu, Sueleyman; Secen, Hasan; Suetbeyaz, Yasar
Helvetica Chimica Acta, 2006 , vol. 89, # 2 p. 270 - 273
反应条件
1: 90 percent / Na / liquid ammonia / 2.5 h / -70 °C
2: diphenylphosphoryl azide; Et3N / benzene / 6 h / Heating
3: benzene / 30 h / Heating
4: 95 percent / H2 / Pd/C / CHCl3; methanol / 24 h / 20 °C
View Scheme
参考文献
Goeksu, Sueleyman; Secen, Hasan; Suetbeyaz, Yasar
Helvetica Chimica Acta, 2006 , vol. 89, # 2 p. 270 - 273
反应条件
1: NaBH4 / aq. ethanol
2: KHSO4
3: (i) MCPBA, CHCl3, (ii) aq. HCl, EtOH
4: aq. NaOH
5: (i) B2H6, THF, (ii) aq. KOH
View Scheme
参考文献
Cannon; O'Donnell; Rosazza; Hoppin
Journal of Medicinal Chemistry, 1974 , vol. 17, # 5 p. 565 - 568
反应条件
1: aq. NaOH
2: (i) B2H6, THF, (ii) aq. KOH
View Scheme
参考文献
Cannon; O'Donnell; Rosazza; Hoppin
Journal of Medicinal Chemistry, 1974 , vol. 17, # 5 p. 565 - 568
反应条件
1: (i) MCPBA, CHCl3, (ii) aq. HCl, EtOH
2: aq. NaOH
3: (i) B2H6, THF, (ii) aq. KOH
View Scheme
参考文献
Cannon; O'Donnell; Rosazza; Hoppin
Journal of Medicinal Chemistry, 1974 , vol. 17, # 5 p. 565 - 568
反应条件
1: KHSO4
2: (i) MCPBA, CHCl3, (ii) aq. HCl, EtOH
3: aq. NaOH
4: (i) B2H6, THF, (ii) aq. KOH
View Scheme
参考文献
Cannon; O'Donnell; Rosazza; Hoppin
Journal of Medicinal Chemistry, 1974 , vol. 17, # 5 p. 565 - 568
