2-氨基-n,5-二甲氧基-n-甲基苯甲酰胺合成路线 （共 4 条）
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in acetonitrile T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/32470 A1, 2006 ;
Location in patent: Page/Page column 32 ;
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in ethanol 0.166667 h; 2: 6-methoxy-1H-benzo[d][1,3]oxazine-2,4-dione in ethanol 2 h; Reflux;
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456
反应条件
1.1: 97 percent / tetrahydrofuran / 18 h / 20 °C 2.1: Et3N / ethanol; H2O / 0.17 h / 20 °C 2.2: ethanol; H2O / 3 h / Heating View Scheme
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Inert atmosphere;
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456
