3,5-二甲氧基苯甲酸甲酯合成路线 （共 80 条）
反应条件
hydrazine hydrate 3 h; Heating;
参考文献
Shen, Zhen Lu; Zhuo, Guang Lan; Jiang, Xuan Zhen
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 11 p. 2395 - 2398
反应条件
1: sodium tetrahydroborate / methanol; tetrahydrofuran / 2.5 h / 70 °C 2: phosphorus tribromide / dichloromethane / 2 h / 20 °C 3: dilithium tetrachlorocuprate View Scheme
参考文献
Nuellen, Max P.; Goettlich, Richard
Synlett, 2013 , vol. 24, # 9 art. no. ST-2012-B1071-L, p. 1109 - 1112
反应条件
1.1: 93.3 percent / N2H4*H2O / 3 h / Heating 2.1: 75.4 percent / K3[Fe(CN)6]; PEG-400; NH3 / toluene; H2O / 4 h / 10 - 20 °C 3.1: NaOMe; tetrabutylammonium iodide / dimethylformamide / 1 h / 20 °C 3.2: 60.7 percent / dimethylformamide / 8 h / 40 °C 4.1: 90 percent / BBr3 / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Shen, Zhen Lu; Zhuo, Guang Lan; Jiang, Xuan Zhen
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 11 p. 2395 - 2398
反应条件
1: 92.3 percent / LiAlH4 / diethyl ether / 4 h / Heating 2: 94.4 percent / SOCl2 / diethyl ether / 3 h / 20 °C 3: 4 h / Heating 4: 68.5 percent / NaOEt / dimethylformamide; ethanol / 3 h / 20 °C View Scheme
参考文献
Chen, Guoliang; Shan, Wei; Wu, Yingliang; Ren, Lixiang; Dong, Jinhua; Ji, Zhizhong
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 12 p. 1587 - 1590
反应条件
1: TiCl4 2: 96 percent / conc. HCl / methanol / 5 h / Heating View Scheme
参考文献
Murty; Hazra; Datta; Mal
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997 , vol. 36, # 2 p. 126 - 132
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 - 20 °C 2.1: triphenylphosphine / dichloromethane / 0.17 h / 20 °C 2.2: -78 - -50 °C 3.1: benzene / 5 h / Reflux View Scheme
参考文献
Tanaka, Ayano; Arai, Yasuhiro; Kim, Su-Nam; Ham, Jungyeob; Usuki, Toyonobu
Journal of Asian Natural Products Research, 2011 , vol. 13, # 4 p. 290 - 296
反应条件
1: LiAlH4 / diethyl ether 2: HBr / benzene 3: (i) Na, EtOH, (ii) /BRN= 2440576/, (iii) aq. NaOH 4: (i) Cu, (ii) polyphosphoric acid View Scheme
参考文献
Huisgen,R. et al.
Justus Liebigs Annalen der Chemie, 1964 , vol. 677, p. 21 - 33
反应条件
(i) LiAlH4, (ii) PBr3; Multistep reaction;
参考文献
Huisgen,R. et al.
Justus Liebigs Annalen der Chemie, 1964 , vol. 677, p. 21 - 33
反应条件
1: sodium hydroxide / 1,4-dioxane / 5 h / 20 °C 2: triethylamine; diphenyl phosphoryl azide / 80 °C View Scheme
参考文献
Song, Yu Min; Ha, Young Mi; Kim, Jin-Ah; Chung, Ki Wung; Uehara, Yohei; Lee, Kyung Jin; Chun, Pusoon; Byun, Youngjoo; Chung, Hae Young; Moon, Hyung Ryong
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7451 - 7455
反应条件
1: (i) LiAlH4, (ii) PBr3 2: ethanol 3: (i) NaOH, MeOH, (ii) /BRN= 102415/ View Scheme
参考文献
Bhati,A.
Tetrahedron, 1962 , vol. 18, p. 1519 - 1526
