3,4-二甲氧基苯甲酸甲酯合成路线 （共 71 条）
反应条件
T=150 - 170°C; im geschlossenen Rohr;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 159, p. 243
Chemische Berichte, , vol. 8, p. 512,1123
Chemische Berichte, , vol. 11, p. 133
参考文献
Monatshefte fuer Chemie, , vol. 3, p. 368,371
Monatshefte fuer Chemie, , vol. 16, p. 94
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=110°C; 24 h;
参考文献
Hwu, Jih Ru; Hsu, Chia Hao; Wong, Fong Fuh; Chung, Chung-Sun; Hakimelahi, Gholam H.
Synthesis, 1998 , # 3 p. 329 - 332
反应条件
1: diluted NaOH-solution 2: diluted hydrochloric acid / 160 - 170 °C / im geschlossenen Rohr 3: HCl View Scheme
参考文献
Matsmoto
Chemische Berichte, 1878 , vol. 11, p. 133
反应条件
1: 70percent HNO3, HOAc 2: SnCl2, HCl 3: NaOH / H2O; methanol View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
n-butyllithium in tetrahydrofuran; hexane; water; acetonitrile
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US6180653 B2, 2001 ;
反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: methyl 3,4-dimethoxybenzoate in tetrahydrofuran; hexane T=-78 - -45°C; Further stages.;
参考文献
Fang, Zhenglai; Song, Yunlong; Sarkar, Taradas; Hamel, Ernest; Fogler, William E.; Agoston, Gregory E.; Fanwick, Phillip E.; Cushman, Mark
Journal of Organic Chemistry, 2008 , vol. 73, # 11 p. 4241 - 4244
反应条件
1: diluted NaOH-solution 2: barytes / beim Gluehen View Scheme
参考文献
Koelle
Justus Liebigs Annalen der Chemie, 1871 , vol. 159, p. 243
参考文献
Clemence; Joliveau-Maushart; Meier; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 257 - 266
反应条件
1: 70percent HNO3, HOAc 2: SnCl2, HCl 3: NaOH / H2O; methanol 4: HOAc / H2O 5: 85 percent / POCl3, PhNMe2 6: NaOH / tetrahydrofuran; H2O View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
