3,4-二羟基苯甲酸甲酯合成路线 （共 60 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0 - 20°C; Mitsunobu reaction; regioselective reaction;
参考文献
Wang, Xiaolong; Ju, Tingting; Li, Xiaodong; Cao, Xiaoping
Synlett, 2010 , # 19 p. 2947 - 2949
反应条件
potassium carbonate in acetonitrile
24 h; Heating;
参考文献
He, Chunlin; Shi, Zuming; Zhou, Qizhong; Li, Shijun; Li, Ning; Huang, Feihe
Journal of Organic Chemistry, 2008 , vol. 73, # 15 p. 5872 - 5880
参考文献
Canonica et al.
Annali di Chimica (Rome, Italy), 1956 , vol. 46, p. 465,473
反应条件
phosphorus pentoxide in toluene
T=75°C; 1 h;
参考文献
Kita, Yasuyuki; Arisawa, Mitsuhiro; Gyoten, Michiyo; Nakajima, Makiko; Hamada, Ryuji; Tohma, Hirofumi; Takada, Takeshi
Journal of Organic Chemistry, 1998 , vol. 63, # 19 p. 6625 - 6633
反应条件
1.1: 77 percent / K2CO3 / CH2Cl2; methanol / 6 h
2.1: 95 percent / KOH / tetrahydrofuran; H2O / 48 h
3.1: 1-methyl-imidazole; p-toluenesulfonyl chloride / acetonitrile
3.2: acetonitrile
4.1: 83 percent / Amberlyst(R) 15 / ethanol; H2O / Heating
View Scheme
参考文献
Schmidt, Rolf; Carrigan, Joseph G.; DeWolf, Christine E.
Canadian Journal of Chemistry, 2006 , vol. 84, # 10 p. 1411 - 1415
反应条件
1: potassium hydroxide; ethanol
2: ethanol; hydrazine hydrate
View Scheme
参考文献
Sun, Juan; Lv, Peng-Cheng; Guo, Feng-Jiao; Wang, Xin-Yi; Han, Xiao-; Zhang, Yang; Sheng, Gui-Hua; Qian, Shao-Song; Zhu, Hai-Liang
European Journal of Medicinal Chemistry, 2014 , vol. 81, p. 420 - 426
反应条件
1: 67 percent / K2CO3 / acetone / 48 h / 20 °C
2: 96 percent / K2CO3 / acetone / 5 h / Heating
3: 94 percent / H2 / Pd/C / methanol / 48 h / 20 °C
View Scheme
参考文献
Desroses, Matthieu; Laconde, Guillaume; Depreux, Patrick; Henichart, Jean-Pierre
Organic Preparations and Procedures International, 2004 , vol. 36, # 5 p. 445 - 452
反应条件
1: 784 g / P2O5 / toluene / 1 h / 75 °C
2: 89 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
3: MnO2
View Scheme
参考文献
Kita, Yasuyuki; Arisawa, Mitsuhiro; Gyoten, Michiyo; Nakajima, Makiko; Hamada, Ryuji; Tohma, Hirofumi; Takada, Takeshi
Journal of Organic Chemistry, 1998 , vol. 63, # 19 p. 6625 - 6633
反应条件
potassium carbonate in acetone
12 h; Heating / reflux;
参考文献
PROTEOTECH, INC.
Patent: WO2005/113489 A1, 2005 ;
Location in patent: Page/Page column 90 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=75°C; 8 h;
参考文献
Percec, Virgil; Peterca, Mihai; Sienkowska, Monika J.; Ilies, Marc A.; Aqad, Emad; Smidrkal, Jan; Heiney, Paul A.
Journal of the American Chemical Society, 2006 , vol. 128, # 10 p. 3324 - 3334
