3,5-二羟基苯甲酸甲酯合成路线 （共 124 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C; 12 h; Inert atmosphere;
参考文献
Schmidt, Bernd; Elizarov, Nelli; Berger, Rene; Hoelter, Frank
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 22 p. 3674 - 3691
反应条件
1: 91 percent / DMAP; DIPEA / CH2Cl2 / 18 h / 18 °C
2: 97 percent / LiAlH4 / tetrahydrofuran / 0 - 18 °C
View Scheme
参考文献
Katoh, Tadashi; Ohmori, Osamu
Tetrahedron Letters, 2000 , vol. 41, # 4 p. 465 - 469
反应条件
1: With sodium hydride
2: With lithium aluminium tetrahydride
参考文献
Neighbors, Jeffrey D.; Salnikova, Maya S.; Wiemer, David F.
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1321 - 1324
反应条件
1: 1.) NaH / 1.) DMF, 24 deg C, 2.) DMF, 24 deg C, 4 h
2: LiAlH4 / tetrahydrofuran / 0.5 h
3: PCC, NaOAc / CH2Cl2 / 3 h / 24 °C
View Scheme
参考文献
Nagata, Toshi
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 2 p. 385 - 391
参考文献
Alonso, Ricardo; Brossi, Arnold
Tetrahedron Letters, 1988 , vol. 29, # 7 p. 735 - 738
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / |Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 16.5 h / 0 - 20 °C / |Inert atmosphere
3: N-bromosuccinmide / dichloromethane / 18 h / 0 °C / |Inert atmosphere
View Scheme
参考文献
Carreras, Javier; Gopakumar, Gopinadhanpillai; Gu, Liangu; Gimeno, Ana; Linowski, Pawel; Petuskova, Jekaterina; Thiel, Walter; Alcarazo, Manuel
Journal of the American Chemical Society, 2013 , vol. 135, # 50 p. 18815 - 18823
反应条件
1: 90 percent / K2CO3 / acetonitrile / 100 °C
2: 98 percent / KOH / ethanol / 4 h / Heating
3: 100 percent / SOCl2 / Heating
4: 74 percent / Na2CO3 / acetone / 4 h / Heating
5: 76 percent / aq. NaOH / tetrahydrofuran / Heating
View Scheme
参考文献
Ziessel, Raymond; Pickaert, Guillaume; Camerel, Franck; Donnio, Bertrand; Guillon, Daniel; Cesario, Michele; Prange, Thierry
Journal of the American Chemical Society, 2004 , vol. 126, # 39 p. 12403 - 12413
反应条件
1: 95 percent / K2CO3 / acetonitrile / 100 °C
2: 94 percent / KOH / ethanol / 4 h / Heating
3: 100 percent / SOCl2 / Heating
4: 72 percent / Na2CO3 / acetone / 4 h / Heating
5: 92 percent / aq. NaOH / tetrahydrofuran / Heating
View Scheme
参考文献
Ziessel, Raymond; Pickaert, Guillaume; Camerel, Franck; Donnio, Bertrand; Guillon, Daniel; Cesario, Michele; Prange, Thierry
Journal of the American Chemical Society, 2004 , vol. 126, # 39 p. 12403 - 12413
反应条件
1: 98 percent / K2CO3 / dimethylformamide / 24 h / 80 °C
2: 98 percent / LiAlH4 / tetrahydrofuran / 12 h / 20 °C
3: 83 percent / PPh3; DIAD / tetrahydrofuran / Heating
4: 86 percent / KOH / methanol; H2O / 60 °C
View Scheme
参考文献
Bury, Izabela; Heinrich, Benoit; Bourgogne, Cyril; Guillon, Daniel; Donnio, Bertrand
Chemistry - A European Journal, 2006 , vol. 12, # 32 p. 8396 - 8413
反应条件
1: 84.4 percent / potassium carbonate; 18-crown-6 / acetone / 24 h / Heating
2: 90.1 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3: 94.8 percent / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0.08 h / 20 °C
4: 83.4 percent / potassium carbonate; 18-crown-6 / acetone / 24 h / Heating
View Scheme
参考文献
Cai, Huanhuan; Jiang, Guoliang; Shen, Zhihao; Fan, Xinghe
Macromolecules, 2012 , vol. 45, # 15 p. 6176 - 6184
