3,5-二羟基苯甲酸甲酯合成路线 （共 124 条）
反应条件
18-crown-6 ether; potassium carbonate in acetone
Etherification; 60 h; Heating;
参考文献
Rheiner, P. Beat; Seebach, Dieter
Chemistry - A European Journal, 1999 , vol. 5, # 11 p. 3221 - 3236
反应条件
1: 96 percent / K2CO3; Adogen 464 / acetone / Heating
2: 86 percent / NaOH / methanol / Heating
View Scheme
参考文献
Ziessel, Raymond; Pickaert, Guillaume; Camerel, Franck; Donnio, Bertrand; Guillon, Daniel; Cesario, Michele; Prange, Thierry
Journal of the American Chemical Society, 2004 , vol. 126, # 39 p. 12403 - 12413
反应条件
1: 1.) K2CO3 / 1.) DMF, 23 deg C, 2 h, 2.) DMF, 23 deg C, 14 h
2: 88 percent / LiAlH4 / diethyl ether / 4 h / 23 °C
3: 96 percent / pyridinium chlorochromate / CH2Cl2 / 3.5 h / 0 °C
4: 1.) NaH / 1.) THF, -5 deg C, 30 min, 2.) THF, RT
View Scheme
参考文献
Thakkar, Kshitij; Geahlen, Robert L.; Cushman, Mark
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2950 - 2955
反应条件
1: 32 percent / potassium carbonate / acetone / 18 h / Heating
2: 89 percent / 1.) lithium aluminium hydride / diethyl ether / 1.) reflux, 3 h, 2.) 16 h
3: phosphorus tribromide / tetrahydrofuran; benzene / 1.) 0 deg C, 2.) 20 deg C, 3.5 h
View Scheme
参考文献
Crombie, Leslie; Jamieson, Sally V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1467 - 1476
反应条件
1: 91 percent / potassium carbonate; 18-crown-6 / acetone / 20 h / Heating
2: 95 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3: 95 percent / CBr4; triphenylphosphine / tetrahydrofuran
4: 98 percent / potassium carbonate; 18-crown-6 / acetone / 18 h / Heating
5: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Bury, Izabela; Heinrich, Benoit; Bourgogne, Cyril; Guillon, Daniel; Donnio, Bertrand
Chemistry - A European Journal, 2006 , vol. 12, # 32 p. 8396 - 8413
反应条件
1: aluminium chloride; diethyl ether / Einleiten von Chlorwasserstoff und Erwaermen des Reaktionsprodukts mit Wasser
2: aq. NaOH solution
View Scheme
参考文献
Birkinshaw; Bracken
Journal of the Chemical Society, 1942 , p. 368
反应条件
potassium carbonate in N,N-dimethyl-formamide; toluene
T=20°C; 16 h;
参考文献
Ballell, Lluis; Van Scherpenzeel, Monique; Buchalova, Katerina; Liskamp, Rob M. J.; Pieters, Roland J.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 23 p. 4387 - 4394
反应条件
1: 96 percent / K2CO3 / acetone / 5 h / 50 °C
2: 91 percent / LiAlH4
3: 90 percent / C5H5*CrO3*HCl / CH2Cl2 / 8 h / 0 °C
4: 92 percent / benzene / 24 h / 25 °C
5: 77 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C
6: 80 percent / H2 / 10 percent Pd/C / ethanol; ethyl acetate / 20 °C
View Scheme
参考文献
Cao, Xiaoping; Wang, Feng; Guo, Shu
Synthetic Communications, 2002 , vol. 32, # 20 p. 3149 - 3158
反应条件
1: 8.6 g / potassium carbonate, potassium iodide / dimethylformamide / 120 h / 50 °C
2: 7.34 g / lithium aluminium hydride / diethyl ether / 0.25 h / Heating
View Scheme
参考文献
Sargent, Melvyn V.; Stanojevic, Edi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 8 p. 1919 - 1921
反应条件
1: 8.6 g / potassium carbonate, potassium iodide / dimethylformamide / 120 h / 50 °C
2: 7.34 g / lithium aluminium hydride / diethyl ether / 0.25 h / Heating
3: 13.6 g / manganese dioxide / benzene / 5 h / Heating
View Scheme
参考文献
Sargent, Melvyn V.; Stanojevic, Edi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 8 p. 1919 - 1921
