3,5-二羟基苯甲酸甲酯合成路线 （共 124 条）
反应条件
1: 85.5 percent / K2CO3; 18-crown-6 / acetone / 48 h / 70 °C 2: 89 percent / LiAlH4 / tetrahydrofuran / 16 h / 20 - 70 °C 3: 57 percent / CBr4; PPh3 / tetrahydrofuran / 20 h / 20 °C View Scheme
参考文献
Sellner, Holger; Faber, Claude; Beat Rheiner; Seebach, Dieter
Chemistry - A European Journal, 2000 , vol. 6, # 20 p. 3692 - 3705
反应条件
samarium(III) trifluoromethanesulfonate T=20°C; 0.166667 h;
参考文献
Roy, Bimalendu; Dasgupta, Somnath; Kumar Rajput, Vishal; Mukhopadhyay, Balaram
Journal of Carbohydrate Chemistry, 2008 , vol. 27, # 1 p. 1 - 9
反应条件
1: 82 percent / K2CO3 / acetone 2: 82 percent / LiAlH4 / tetrahydrofuran 3: 35 percent / PPh3, DEAD View Scheme
参考文献
Connolly, Cleo J. C.; Hamby, James M.; Schroeder, Mel C.; Barvian, Mark; Lu, Gina H.; Panek, Robert L.; Amar, Aneesa; Shen, Cindy; Kraker, Alan J.; Fry, David W.; Klohs, Wayne D.; Doherty, Annette M.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2415 - 2420
反应条件
1: 91 percent / potassium carbonate; 18-crown-6 / acetone / 20 h / Heating 2: 95 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Chen, Zhen; Xue, Cuihua; Shi, Wei; Luo, Fen-Tair; Green, Sarah; Chen, Jian; Liu, Haiying
Analytical Chemistry, 2004 , vol. 76, # 21 p. 6513 - 6518
反应条件
18-crown-6 ether; potassium carbonate in acetone 60 h; Heating;
参考文献
Pan, Jianfeng; Zhu, Weihong; Li, Shangfeng; Xu, Jun; Tian, He
European Journal of Organic Chemistry, 2006 , # 4 p. 986 - 1001
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=0 - 20°C;
参考文献
Zimmerman, Steven C.; Zharov, Ilya; Wendland, Michael S.; Rakow, Neal A.; Suslick, Kenneth S.
Journal of the American Chemical Society, 2003 , vol. 125, # 44 p. 13504 - 13518
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
Iwata, Hidehisa; Kohara, Yasuhisa; Cao, Sheldon X.; Guntupalli, Prasuna; Gwaltney, Stephen L.; Hosfield, David J.; Liu, Yan; Stafford, Jeffrey A.; Throop, Beverly
Patent: US2010/69431 A1, 2010 ;
Location in patent: Page/Page column 104 ;
反应条件
potassium carbonate in acetone
参考文献
Connolly, Cleo J. C.; Hamby, James M.; Schroeder, Mel C.; Barvian, Mark; Lu, Gina H.; Panek, Robert L.; Amar, Aneesa; Shen, Cindy; Kraker, Alan J.; Fry, David W.; Klohs, Wayne D.; Doherty, Annette M.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2415 - 2420
反应条件
1: 39 percent / NaH / dimethylformamide 2: 13 percent / aq. KOH / methanol View Scheme
参考文献
Koolaji, Nooshin; Abu-Mellal, Abdallah; Tran, Van H.; Duke, Rujee K.; Duke, Colin C.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 415 - 422
反应条件
sodium methylate Behandeln des Reaktionsprodukts mit wss. Kalilauge;
参考文献
Bonjean; Schunack
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 4 p. 501 - 507
